This ITC working group seminar series aims to provide informational background on existing or newly emerging case studies of humanized mouse models from various organizations, including The Jackson Laboratory, Taconic Biosciences, AstraZeneca, and the US Food and Drug Administration. The working group seeks to better understand the advantages or potential limitations of each model, as well as address how these models could be improved in order to be utilized for drug discovery and safety risk assessment.
The virtual seminar series is open to ITC Committee participants only. Click here to learn more about the HESI ITC Committee.
Seminar Series Speakers & Titles:
19 February 2021: James Keck, PhD, The Jackson Laboratory
"Utilization of an In Vitro PBMC Humanized Mouse Model for Determining Bispecific Antibody-Related Cytokine Release Syndrome"
19 March 2021: Janell Richardson, PhD, Taconic Biosciences
"A Case Study on Variance and Its Implications on Study Design in the huNOG-EXL"
16 April 2021: Giovanni Pellegrino, DVM, PhD, AstraZeneca
"Pathology of Mice With a Human Immune System: The Price of Humanization"
21 May 2021: Kristina Howard, PhD, US Food and Drug Administration