Developing and using specific imaging technologies (e.g., micro-CT, MRI) allows for alternative methods for evaluating structural birth defects in animal models. As the technology develops increased capabilities and speed, this technique could eventually become a high-throughput method and allow for sharing of images between laboratories and regulatory agencies. In practice, it will eliminate the use of large quantities of processing chemicals and wet-specimen archives. At this time, the technical methods, the alterations observed, and their interpretation have not yet gained general regulatory acceptance. In order to facilitate acceptance, a set of criteria will be developed that would help organizations validate their individual imaging systems and provide the basis for acceptance of these technologies by the regulatory community.
This workshop aims to:
The final workshop program is available here.
Session 1: Background and Introduction
Session 2: Using micro-CT for Fetal Skeletal Evaluations
Session 3: "Concordance" Criteria - How Do We Define Scientific Agreement?
Session 4: General Principles of Validation
Session 5: Summary & Discussion of Future Issues
Please contact Dr. Connie Chen (firstname.lastname@example.org) for additional information.