Uncertainty in Torsade Risk due to Different Possible Kinetic Binding Mechanisms for hERG

The Cardiac Safety Steering Team is proud to present the second webinar series featuring the 2024 Early Career Seminar Series Awardees.

This competitive award is given to postdoctoral or early career scientists who have compelling research related to cardiovascular safety and risk assessment.

Three awardees were selected for the 2024 Seminar Series:

• Dr. Chon Lok Lei, February 22 at 9am ET
• Dr. Victoria Au Yueng, March 22 at 11am ET
• Dr. Alexandra Schaffert, April 5 at 11am ET

For webinar link contact: HESI Cardiac Safety cardiacsafety@hesiglobal.org

Title: Uncertainty in Torsade Risk due to Different Possible Kinetic Binding Mechanisms for hERG

Bio: Chon Lok Lei is an Assistant Professor of Biomedical Sciences, a principal investigator, at the University of Macau. He completed his doctoral degree as a Clarendon scholar at the Computational Biology group in the Department of Computer Science at the University of Oxford, working collaboratively with a research team at Roche. He received his undergraduate degree and the Dean’s List in Physics from Imperial College London. He has strong research interests in mathematical and computational modelling of biological and physiological systems and their applications in cardiac safety pharmacology. His recent work provides a novel pipeline for quantifying the uncertainty in binding mechanisms and propagating to clinical risk predictions.