A 2-day workshop to address the state of the science and data gaps in gut microbiome research.
The Gut Microbiome Workshop
June 25, 2018 – June 26, 2018
Alexandria, VA, United States
June 25, 2018 – June 26, 2018
Alexandria, VA, United States
A 2-day workshop to address the state of the science and data gaps in gut microbiome research.
June 12, 2018 – June 13, 2018
Washington, DC, USA
May 15, 2018 – May 16, 2018
Boston, Massachusetts, USA
The Cardiac Safety Committee convened a 2-day workshop to discuss mechanistic approaches to cardiovascular safety assessment.
May 2, 2018 – May 5, 2018
Montreal, Canada
For the second consecutive year, the CT-TRACS Committee will participate in a 4-day annual meeting organized by the International Society for Cellular Therapy.
April 4, 2018 – April 5, 2018
Munich , Germany
The field of immunotoxicology is a dynamic one in which changing public health concerns, novel biomedical research advances, and innovative technological developments constantly change the landscape and the way in which work is carried out and utilized. As this field requires combined expertise in both immunology and ...
March 22, 2018 – March 23, 2018
Potsdam, Germany
Applied genetic toxicology is undergoing a major paradigm shift towards changing the strategies employed for assessment of chemically-induced genomic damage, evaluation methods of the mechanisms by which that damage translates into adverse effects, and the quantitative methods used to interpret dose-response data. This ...
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The Gut Microbiome: Markers of Human Health,
Drug Efficacy and Xenobiotic Toxicity
June 25 - 26
Holiday Inn & Suites Alexandria - Old Town
625 First Street
Alexandria, Virginia
The gut microbiome is believed to play an important role in human health in areas as diverse as brain function and the immune system. Exploring host-microbiome interactions will provide a mechanistic understanding and enable new insights in human diseases (i.e., their diagnosis, prognosis and treatment) and new perceptions of xenobiotic efficacy and/or toxicity. This workshop will review the science and initiate discussions on multiple topics, including a) identification of biomarkers of toxicity for alterations in gut microbial function, b) if changes in the microbiome can affect efficacy of medicines and c) if exposure to xenobiotics can eventually result in a disease state through changes in the microbiome. Conclusions from his workshop will help determine where the data gaps are so that researchers can start answering these questions.
WORKSHOP GOAL
To identify data gaps that can be addressed to help determine if alterations in the gut microbiome have an effect on human health.
WORKSHOP AIMS
1. To discuss and review the current science on the gut microbiome and identify areas of interest regarding its role in human health
2. To discuss our understanding on how xenobiotic toxicity affects the microbiome
3. To understand if there are biomarkers of disease or organ damage due to:
- Alterations of microbiome structure and function
- Endogenous microbial metabolites
Workshop Agenda [Download Agenda]
Plenary
Drugging Gut Microbial Enzymes for the Treatment of Cardiometabolic Disease
Mark Brown, Cleveland Clinic
Session 1: Biotransformation
Overview of Biotransformation of Xenobiotics by Microbiota
Julia Cui, University of Washington [Download Presentation]
Gut Microbial Transformation – Endogenous and Exogenous Metabolites & Effect of Xenobiotics on Microbial Composition and Endogenous Functions
Gary Perdew, Penn State University
Modification of Chemical Effects by Microbiome?
Andrew Patterson, Penn State University
Session 2: Biomarkers of Adverse Effects
What is an Adverse Effect?
Rodney Dietert, Cornell University [Download Presentation]
Where to Look for Biomarkers?
Carrie Brodmerkel, Janssen [Download Presentation]
Challenges in Determining Sensitive Biomarkers of Dysbiosis When Assessing the Impact of Antimicrobial Drug Residues in Food on the Human Intestinal Microbiome
Carl Cerniglia, US FDA-NCTR [Download Presentation]
What are the Tools and Technologies Needed?
Joseph Petrosino, Baylor College of Medicine [Download Presentation]
Session 3: Biomarkers of Toxicity & Disease
Toxicity and Environmental Pollutants
Kun Lu, University of North Carolina Chapel Hill
Identification of Microbiome-based Biomarkers and Challenges Associated with their Application: Case Studies from Obesity, IBD, and Cancer
Emily Hollister, Diversigen [Download Presentation]
The Microbiome and Hypertension
Elaine Richards Sumners, University of Florida [Download Presentation]
Session 4: Human Susceptibility
Health Insights from Microbiomes in the Context of Personal, Dense, Dynamic, Data Clouds
Nathan Price, Institute for Systems Biology
Age – Early & Late Life
Eugene Chang, University of Chicago [Download Presentation]
Gender and the Gut Microbiome
Marijke Faas, University of Groningen
Session 5: Key Animal Models
Overview of Key Factors Known to Affect Composition of Laboratory Rodent Gut Microbiome
Aaron Ericsson, University of Missouri [Download Presentation]
Natural World Versus Laboratory World: Natural Gut Microbiota from Wild Mice Improve Host Fitness in Viral Infection and Carcinogenesis Models
Barbara Rehermann, NIH/NIDDK [Download Presentation]
Investigating Interactions Between Chemicals and Microbiota in Zebrafish
Tamara Tal, US EPA
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Workshop Agenda
Workshop Objectives
Mirjam Luitjen, RIVM
Path Forward for Genetic Toxicity Assessment
Kerry Dearfield, Former USDA
The New Strategy in Practice: Case Study Examples
Veronique Thybaud, Sanofi & Nicholas Ball, DOW
Incorporating Mode of Action into Genetic Toxicity Assessment
Roland Frötschl, BfArM, Germany
Novel Approaches and Technologies to Assess Genotoxic Modes of Action
Stefan Pfuhler, Procter & Gamble
Genetic Toxicity Mini-Adverse Outcome Pathways (mini-AOPs)
Azeddine Elhajouji, Novartis
Approaches for Analyses and Interpretation of Genetic Toxicity Dose-Response
Paul White, Health Canada
Quantitative Dose-Response Analyses for Risk Assessment and Regulatory Decision Making: Issues, Applications, and Challenges
George Johnson, Swansea University
Background and Objectives
Applied genetic toxicology is undergoing a major paradigm shift towards changing the strategies employed for assessment of chemically-induced genomic damage, evaluation methods of the mechanisms by which that damage translates into adverse effects, and the quantitative methods used to interpret dose-response data. This shift entails a movement away from simple dichotomous evaluations of genotoxicity (i.e., yes/no), that only supports identification of potential carcinogens, and towards a greater understanding of the diversity of adverse outcomes related to genomic damage, of the multitude of mechanisms (or modes of action) underscoring genomic damage, and the ability to determine point of departure metrics for human health risk assessment and regulatory decision making. Moreover, advanced technologies to investigate genotoxic mechanisms and to analyze dose-response functions are being developed and incorporated into assessments of genomic damage.
This workshop was organized by the HESI Genetic Toxicology Technical Committee (GTTC). The HESI GTTC brings together an international cohort of genetic toxicologists from industry, academia, and government to address issues related to all aspects of genetic toxicity assessment. These aspects include the development and validation of assessment approaches, technologies and strategies for mode-of-action determination, and approaches for data interpretation. The GTTC is comprised of experts in the fields of genetic and general toxicology, risk assessment, and computational biology. The workshop will examine a new generation of testing strategy for assessment of genomic damage, new approaches and technologies for mode-of-action determination and interpretation, and recent developments in quantitative interpretation of genetic toxicity dose-response data.
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The Gut Microbiome: Markers of Human Health,
Drug Efficacy and Xenobiotic Toxicity
June 25 - 26
Holiday Inn & Suites Alexandria - Old Town
625 First Street
Alexandria, Virginia
The gut microbiome is believed to play an important role in human health in areas as diverse as brain function and the immune system. Exploring host-microbiome interactions will provide a mechanistic understanding and enable new insights in human diseases (i.e., their diagnosis, prognosis and treatment) and new perceptions of xenobiotic efficacy and/or toxicity. This workshop will review the science and initiate discussions on multiple topics, including a) identification of biomarkers of toxicity for alterations in gut microbial function, b) if changes in the microbiome can affect efficacy of medicines and c) if exposure to xenobiotics can eventually result in a disease state through changes in the microbiome. Conclusions from his workshop will help determine where the data gaps are so that researchers can start answering these questions.
WORKSHOP GOAL
To identify data gaps that can be addressed to help determine if alterations in the gut microbiome have an effect on human health.
WORKSHOP AIMS
1. To discuss and review the current science on the gut microbiome and identify areas of interest regarding its role in human health
2. To discuss our understanding on how xenobiotic toxicity affects the microbiome
3. To understand if there are biomarkers of disease or organ damage due to:
- Alterations of microbiome structure and function
- Endogenous microbial metabolites
Workshop Agenda [Download Agenda]
Plenary
Drugging Gut Microbial Enzymes for the Treatment of Cardiometabolic Disease
Mark Brown, Cleveland Clinic
Session 1: Biotransformation
Overview of Biotransformation of Xenobiotics by Microbiota
Julia Cui, University of Washington [Download Presentation]
Gut Microbial Transformation – Endogenous and Exogenous Metabolites & Effect of Xenobiotics on Microbial Composition and Endogenous Functions
Gary Perdew, Penn State University
Modification of Chemical Effects by Microbiome?
Andrew Patterson, Penn State University
Session 2: Biomarkers of Adverse Effects
What is an Adverse Effect?
Rodney Dietert, Cornell University [Download Presentation]
Where to Look for Biomarkers?
Carrie Brodmerkel, Janssen [Download Presentation]
Challenges in Determining Sensitive Biomarkers of Dysbiosis When Assessing the Impact of Antimicrobial Drug Residues in Food on the Human Intestinal Microbiome
Carl Cerniglia, US FDA-NCTR [Download Presentation]
What are the Tools and Technologies Needed?
Joseph Petrosino, Baylor College of Medicine [Download Presentation]
Session 3: Biomarkers of Toxicity & Disease
Toxicity and Environmental Pollutants
Kun Lu, University of North Carolina Chapel Hill
Identification of Microbiome-based Biomarkers and Challenges Associated with their Application: Case Studies from Obesity, IBD, and Cancer
Emily Hollister, Diversigen [Download Presentation]
The Microbiome and Hypertension
Elaine Richards Sumners, University of Florida [Download Presentation]
Session 4: Human Susceptibility
Health Insights from Microbiomes in the Context of Personal, Dense, Dynamic, Data Clouds
Nathan Price, Institute for Systems Biology
Age – Early & Late Life
Eugene Chang, University of Chicago [Download Presentation]
Gender and the Gut Microbiome
Marijke Faas, University of Groningen
Session 5: Key Animal Models
Overview of Key Factors Known to Affect Composition of Laboratory Rodent Gut Microbiome
Aaron Ericsson, University of Missouri [Download Presentation]
Natural World Versus Laboratory World: Natural Gut Microbiota from Wild Mice Improve Host Fitness in Viral Infection and Carcinogenesis Models
Barbara Rehermann, NIH/NIDDK [Download Presentation]
Investigating Interactions Between Chemicals and Microbiota in Zebrafish
Tamara Tal, US EPA
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