Cardiac Test

Mission Statement

The mission of the HESI Cardiac Safety Committee is to improve public health by reducing unanticipated cardiovascular-related adverse effects from drugs or chemicals, and to develop innovative approaches to support early detection and prediction as well as improved understanding of cardiovascular toxicology and pathobiology.

Cardiac Safety Committee Early Career Seminar Award Series

The HESI Cardiac Safety Committee is excited to announce that applications are now being accepted for the committee’s new Early Career Seminar Award Series. This award offers an opportunity for postdocs and early career scientists to share their research, learn from, and network with experts in the toxicology and safety pharmacology fields from academia, regulatory agencies, and pharmaceutical companies. Selected candidates will receive a $500 USD award and will be invited to present their research on a public webinar with Cardiac Safety Committee members and other invited guests. Webinar dates will be scheduled with the awardees in Q1 2022.

The deadline to apply is 1 December 2021. To learn more and to apply, please click here.

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Latest Publications

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Validating and Using Cardiac NAMs for Toxicity Screening and Drug Development

International Journal of Toxicology, 2025

Pierson et al.

This work addresses longstanding challenges in drug development, where traditional animal models often fail to predict human cardiac outcomes. Through a multi-year FDA-funded grant, the committee assessed the performance of new approach methodologies (NAMs), including human-induced pluripotent stem cell–derived ...

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Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium

Journal of Pharmacological and Toxicological Methods, 2024

Boulay et al.

The HESI Cardiac Safety Committee has published a new study in the Journal of Pharmacological and Toxicological Methods exploring the use of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) intervals as potential biomarkers for assessing drug-induced proarrhythmia risk in nonclinical species.

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Health and Environmental Sciences Institute (HESI)

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