Cardiac Test

Mission Statement

The mission of the HESI Cardiac Safety Committee is to improve public health by reducing unanticipated cardiovascular-related adverse effects from drugs or chemicals, and to develop innovative approaches to support early detection and prediction as well as improved understanding of cardiovascular toxicology and pathobiology.

Cardiac Safety Committee Early Career Seminar Award Series

The HESI Cardiac Safety Committee is excited to announce that applications are now being accepted for the committee’s new Early Career Seminar Award Series. This award offers an opportunity for postdocs and early career scientists to share their research, learn from, and network with experts in the toxicology and safety pharmacology fields from academia, regulatory agencies, and pharmaceutical companies. Selected candidates will receive a $500 USD award and will be invited to present their research on a public webinar with Cardiac Safety Committee members and other invited guests. Webinar dates will be scheduled with the awardees in Q1 2022.

The deadline to apply is 1 December 2021. To learn more and to apply, please click here.

Test

  • Test123

    Test123Test123Test123Test123Test123Test123Test123Test123Test123Test123Test123

  • Test13244Test123

    Test123Test123Test123Test123Test123

Latest Publications

Filter

The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis

Members of the HESI Cardiac Safety Committee pooled retrospective data to explore the incidence of spontaneous arrhythmias and effect of telemetry implants in species typically used in safety pharmacology studies.

Read more

The Challenges of Predicting Drug-Induced QTc Prolongation in Humans

New publication in Toxicological Sciences by the HESI Cardiac Safety Committee shows that nonclinical models used to predict cardiac safety during drug development do not absolutely replicate the clinical conditions; however, best practices can be used to improve the nonclinical assay quality and achieve the ...

Read more

Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy

The study (Pugsley et al., 2021. Journal of Pharmacological and Toxicological Methods) focused on the effects of high versus low dietary fat on the development of Type 2 diabetes in obese male ZDF rats, including biomarkers to detect early signs of hypercoagulability and vascular injury in the absence of overt thrombosis. Results ...

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => Cardiac Safety
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Cardiac Safety
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => Cardiac Safety
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Cardiac Safety
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [taxonomy] => ilsi_committee
            [term_id] => Cardiac Safety
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [terms] => Array
                                (
                                    [0] => Cardiac Safety
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_term_relationships
                )

            [queried_terms] => Array
                (
                    [ilsi_committee] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Cardiac Safety
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id) INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )
					WHERE 1=1  AND ( 
  wp_term_relationships.term_taxonomy_id IN (17)
) AND ( 
  wp_postmeta.meta_key = '_ilsi_date'
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 0, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 27945
                    [post_author] => 16
                    [post_date] => 2024-04-09 18:19:45
                    [post_date_gmt] => 2024-04-09 18:19:45
                    [post_content] => 
                    [post_title] => Development of a Pharmaceutical Database as an Aid to the Nonclinical Detection of Drug-Induced Cardiac Toxicity
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => development-of-a-pharmaceutical-database-as-an-aid-to-the-nonclinical-detection-of-drug-induced-cardiac-toxicity
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2024-04-18 14:52:30
                    [post_modified_gmt] => 2024-04-18 14:52:30
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=27945
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 27879
                    [post_author] => 16
                    [post_date] => 2024-03-28 13:21:32
                    [post_date_gmt] => 2024-03-28 13:21:32
                    [post_content] => 
                    [post_title] => Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => challenging-the-status-quo-a-framework-for-mechanistic-and-human-relevant-cardiovascular-safety-screening
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2024-04-09 18:40:31
                    [post_modified_gmt] => 2024-04-09 18:40:31
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=27879
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 26584
                    [post_author] => 16
                    [post_date] => 2023-03-31 13:33:31
                    [post_date_gmt] => 2023-03-31 13:33:31
                    [post_content] => 
                    [post_title] => The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => cardiac-safety-pubication-03-02-2023
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-03-31 13:34:10
                    [post_modified_gmt] => 2023-03-31 13:34:10
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=26584
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 27179
                    [post_author] => 16
                    [post_date] => 2023-08-21 13:42:08
                    [post_date_gmt] => 2023-08-21 13:42:08
                    [post_content] => 
                    [post_title] => Comprehensive Collection of Current Methods for Contractility and Electrophysiology Recordings in Human Cardiac Cells
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => comprehensive-collection-of-current-methods-for-contractility-and-electrophysiology-recordings-in-human-cardiac-cells
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-08-21 13:42:08
                    [post_modified_gmt] => 2023-08-21 13:42:08
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=27179
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 24853
                    [post_author] => 16
                    [post_date] => 2022-04-01 12:01:31
                    [post_date_gmt] => 2022-04-01 12:01:31
                    [post_content] => 
                    [post_title] => The Challenges of Predicting Drug-Induced QTc Prolongation in Humans
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-challenges-of-predicting-drug-induced-qtc-prolongation-in-humans
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-04-01 12:34:11
                    [post_modified_gmt] => 2022-04-01 12:34:11
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=24853
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 23746
                    [post_author] => 2
                    [post_date] => 2020-11-10 18:31:59
                    [post_date_gmt] => 2020-11-10 18:31:59
                    [post_content] => 
                    [post_title] => Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => use-of-the-zdf-rat-to-model-dietary-fat-induced-hypercoagulability-is-limited-by-progressive-and-fatal-nephropathy
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-11-21 17:00:31
                    [post_modified_gmt] => 2023-11-21 17:00:31
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=23746
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 27945
            [post_author] => 16
            [post_date] => 2024-04-09 18:19:45
            [post_date_gmt] => 2024-04-09 18:19:45
            [post_content] => 
            [post_title] => Development of a Pharmaceutical Database as an Aid to the Nonclinical Detection of Drug-Induced Cardiac Toxicity
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => development-of-a-pharmaceutical-database-as-an-aid-to-the-nonclinical-detection-of-drug-induced-cardiac-toxicity
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2024-04-18 14:52:30
            [post_modified_gmt] => 2024-04-18 14:52:30
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=27945
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 40
    [max_num_pages] => 7
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 1
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 51132fe6b5066e52d82f3e15020af58f
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.