Transforming the Evaluation of Agrochemicals: A Conceptual Model

We are pleased to announce a new publication from HESI Global’s Committee on Transforming the Evaluation of Agrochemicals (TEA): “Transforming the Evaluation of Agrochemicals: A Conceptual Model” in Regulatory Toxicology and Pharmacology.

As global demand for safe and sustainable food production intensifies, traditional agrochemical safety assessments, often heavily reliant on animal testing, are struggling to keep pace with scientific advancements. The TEA Committee tackled this challenge head-on by creating a conceptual model designed to modernize agrochemical evaluation.

What’s New: The TEA model introduces a fit-for-purpose, exposure-driven, and science-inclusive framework, layered with principles of adaptability, transparency, data-sharing, and trust-building. It shifts the paradigm from a hazard-first to an exposure-first approach, leveraging New Approach Methodologies (NAMs) to support humane, efficient, and scientifically robust risk assessments.

Why It Matters: This model addresses both global and local regulatory needs, reducing unnecessary animal testing while maintaining rigorous safety standards. It empowers regulators to make timely, science-driven decisions that protect human and environmental health, advancing HESI Global’s mission to resolve pressing global challenges.

Read the full article here: Transforming the Evaluation of Agrochemicals: A Conceptual Model. Yadvinder et al., 2025. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2025.105889