Publication from the HESI Developmental and Reproductive Toxicology Committee delivering critical guidance to reduce unnecessary non-human primate (NHP) use in reproductive toxicology studies.
This paper introduces a transparent, stepwise framework to determine when NHP use in DART studies is truly warranted. It helps ensure regulatory confidence while aligning with the 3Rs (Replacement, Reduction, Refinement).
Bowman et al., 2025. Minimizing use of non-human primates to inform risk to fertility and adverse pregnancy outcomes with pharmaceuticals. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2025.105971
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