Detection of contractility changes in the heart from arterial blood pressure data using symmetric Projection Attractor Reconstruction

The HESI Cardiac Safety Committee is excited to announce the publication of its latest study titled “Detection of Contractility Changes in the Heart from Arterial Blood Pressure Data Using Symmetric Projection Attractor Reconstruction” in the Journal of Pharmacological and Toxicological Methods.

This innovative study addresses a critical challenge in cardiovascular safety assessment—detecting drug-induced changes in cardiac contractility. Traditionally, left ventricular pressure (LVP) measurements, which are invasive and resource-intensive, have been the gold standard. However, this study introduces a novel method using Symmetric Projection Attractor Reconstruction (SPAR) to analyze arterial blood pressure (BP) signals as a non-invasive surrogate for LVP.

Key takeaways from the study include:

• The SPAR method demonstrated a high correlation (≥0.8) with LVP measurements, outperforming conventional BP metrics across various drugs and doses.
• This technique offers a less invasive, more efficient approach to screen for potential cardiotoxicity in non-clinical drug development, potentially reducing the need for direct LVP measurements.
• The findings suggest that SPAR analysis could become a valuable tool in early-stage drug development, enhancing the safety and efficiency of cardiovascular assessments.

This publication marks a significant advancement in the field, offering a promising alternative to traditional methods and aligning with the goals of reducing animal testing and improving data reproducibility.

Read the full paper at the link below:
Detection of contractility changes in the heart from arterial blood pressure data using symmetric Projection Attractor Reconstruction. Bonet-Luz et al., 2024. Journal of Pharmacological and Toxicological Methods. https://doi.org/10.1016/j.vascn.2024.107546