The Health and Environmental Sciences Institute's (HESI) Next Generation Ecological Risk Assessment Committee is proud to announce the release of new publication: "Control Performance of Amphibian Metamorphosis Assays with Xenopus laevis."
This study addresses variability challenges in the Amphibian Metamorphosis Assay (AMA), a widely used assay to detect the endocrine-disrupting effects of chemicals on the thyroid system. By analyzing data from 52 studies across seven laboratories, the paper highlights how variability in controls affects the assay's reliability and provides actionable solutions to improve its consistency and interpretability.
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Read the full article at the link below:
Control Performance of Amphibian Metamorphosis Assays with Xenopus laevis. Wheeler et al., 2025. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2025.105773
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