Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium

This article addresses the growing public health concerns surrounding the use of botanical supplements and herbal products, focusing on their potential to cause liver toxicity and dangerous drug interactions. As the popularity of these products increases, so do cases of adverse effects, including drug-induced liver injury (DILI). The paper highlights the need for advanced safety testing methods, such as 3D liver models and in vitro tools, to more accurately predict and prevent these risks. Based on discussions from the HESI Botanical Safety Consortium session, held at the Society of Toxicology Meeting in March 2024, the report features insights from regulators, researchers, and industry experts who call for improved safety frameworks and collaboration to protect consumers. Readers interested in botanical safety, toxicology, or regulatory science will find this paper's exploration of cutting-edge solutions highly relevant.

Koturbash et al., 2024. Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium. Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/j.yrtph.2024.105708