Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
Filter

The Use of Mode of Action Information in Risk Assessment: Quantitative Key Events/Dose-Response Framework for Modeling the Dose-Response for Key Events

Critical Reviews in Toxicology, 2014

Simon TW, Simons SS, Preston RJ, Boobis AR, Cohen SM, Doerrer NG, ...
  • HESI - Health and Environmental Sciences Institute

The HESI RISK21 project formed the Dose-Response/Mode-of-Action Subteam to develop strategies for using all available data (in vitro, in vivo, and in silico) to advance the next-generation of chemical risk assessments.

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 8
            [orderby] => title
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 8
            [orderby] => title
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_key] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [suppress_filters] => 
            [ignore_sticky_posts] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [meta_table] => 
            [meta_id_column] => 
            [primary_table] => 
            [primary_id_column] => 
            [table_aliases:protected] => Array
                (
                )

            [clauses:protected] => Array
                (
                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts 
					WHERE 1=1  AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					
					ORDER BY wp_posts.post_title DESC
					LIMIT 42, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 3421
                    [post_author] => 6
                    [post_date] => 2016-06-27 16:44:41
                    [post_date_gmt] => 2016-06-27 21:44:41
                    [post_content] => 
                    [post_title] => The Utility of DNA Microarrays for Characterizing Genotoxicity
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-utility-of-dna-microarrays-for-characterizing-genotoxicity
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-27 16:44:41
                    [post_modified_gmt] => 2016-06-27 21:44:41
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3421
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 3347
                    [post_author] => 6
                    [post_date] => 2016-06-26 19:58:30
                    [post_date_gmt] => 2016-06-27 00:58:30
                    [post_content] => 
                    [post_title] => The Utility of an International Sera Bank for Use in Evaluating the Potential Human Allergenicity of Novel Proteins
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-utility-of-an-international-sera-bank-for-use-in-evaluating-the-potential-human-allergenicity-of-novel-proteins
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-26 19:58:30
                    [post_modified_gmt] => 2016-06-27 00:58:30
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3347
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 3450
                    [post_author] => 6
                    [post_date] => 2016-06-27 20:28:41
                    [post_date_gmt] => 2016-06-28 01:28:41
                    [post_content] => 
                    [post_title] => The Use of the Rat in Developmental Immunotoxicology Studies
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-use-of-the-rat-in-developmental-immunotoxicology-studies
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-27 20:28:41
                    [post_modified_gmt] => 2016-06-28 01:28:41
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3450
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 2584
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:23:43
                    [post_date_gmt] => 2016-05-05 01:23:43
                    [post_content] => 
                    [post_title] => The Use of Optical Imaging to Assess the Potential for Embryo-Fetal Exposure to an Exogenous Material After Intravaginal Administration
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-use-of-optical-imaging-to-assess-the-potential-for-embryo-fetal-exposure-to-an-exogenous-material-after-intravaginal-administration
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:23:43
                    [post_modified_gmt] => 2016-05-05 01:23:43
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2584
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 2625
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:17:42
                    [post_date_gmt] => 2016-05-05 01:17:42
                    [post_content] => 
                    [post_title] => The Use of Mode of Action Information in Risk Assessment: Quantitative Key Events/Dose-Response Framework for Modeling the Dose-Response for Key Events
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-use-of-mode-of-action-information-in-risk-assessment-quantitative-key-eventsdose-response-framework-for-modeling-the-dose-response-for-key-events
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:17:42
                    [post_modified_gmt] => 2016-05-05 01:17:42
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2625
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 3352
                    [post_author] => 6
                    [post_date] => 2016-06-26 21:21:29
                    [post_date_gmt] => 2016-06-27 02:21:29
                    [post_content] => 
                    [post_title] => The Use of Biomonitoring Data in Exposure and Human Health Risk Assessments
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-use-of-biomonitoring-data-in-exposure-and-human-health-risk-assessments
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-26 21:21:29
                    [post_modified_gmt] => 2016-06-27 02:21:29
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3352
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 3421
            [post_author] => 6
            [post_date] => 2016-06-27 16:44:41
            [post_date_gmt] => 2016-06-27 21:44:41
            [post_content] => 
            [post_title] => The Utility of DNA Microarrays for Characterizing Genotoxicity
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => the-utility-of-dna-microarrays-for-characterizing-genotoxicity
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2016-06-27 16:44:41
            [post_modified_gmt] => 2016-06-27 21:44:41
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=3421
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 472
    [max_num_pages] => 79
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 1
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 4f34cf1ccacea9f0cd451c516023975c
    [query_vars_changed:WP_Query:private] => 1
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.