Journal of Pharmacological and Toxicological Methods, 2021
Pugsley MK, Brooks MB, Fishman CE, Katavolos P, Chiang AY, ...
Zucker diabetic fatty (ZDF) rats are used widely as an animal model of metabolic syndrome and insulin resistance. Our study focused on the effects of high versus low dietary fat on the development of Type 2 diabetes in obese male ZDF rats (fa/fa), including biomarkers to detect early signs of hypercoagulability and vascular injury ...
Critical Reviews in Toxicology , 2015
Doe JE, Lander DR, Doerrer NG, Heard N, Hines RN, Lowit AB, ...
- HESI - Health and Environmental Sciences Institute
The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether additional refinement is required to obtain the necessary precision level for a decision regarding safety.
Integrated Environmental Assessment and Management, 2015
van den Brink NW, Arblaster JA, Bowman SR, Conder JM, Elliott JE, ...
- HESI - Health and Environmental Sciences Institute
Field-based studies are an essential component of research addressing the behavior of organic chemicals, and a unique line of evidence that can be used to assess bioaccumulation potential in chemical registration programs and aid in development of associated laboratory and modeling efforts.
Journal of Agricultural and Food Chemistry, 2009
Jackson SH, Cowan-Ellsberry CE, Thomas G
- HESI - Health and Environmental Sciences Institute
The focus of this research was to develop a model based solely on molecular descriptors capable of predicting fish bioconcentration factors (BCF).
Human and Ecological Risk Assessment, 2007
Nichols J, Erhardt S, Dyer S, James M, Moore M, Plotzke K, ...
- HESI - Health and Environmental Sciences Institute
A scientific workshop was held in 2006 to discuss the use of in vitro Absorption, Distribution, Metabolism, and Excretion (ADME) data in chemical bioaccumulation assessments for fish.
2003
Robinson DE, Pettit SD, Morgan DG
- HESI - Health and Environmental Sciences Institute
This book chapter was published in Toxicogenomics.
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