Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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The Challenges of Predicting Drug-Induced QTc Prolongation in Humans

Toxicological Sciences, 2022

Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, ...

New publication in Toxicological Sciences by the HESI Cardiac Safety Committee shows that nonclinical models used to predict cardiac safety during drug development do not absolutely replicate the clinical conditions; however, best practices can be used to improve the nonclinical assay quality and achieve the ...

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AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations

Environmental and Molecular Mutagenesis, 2022

Eunnara Cho, Ashley Allemang, Marc Audebert, Vinita Chauhan, ...

HESI Genetic Toxicology Technical Committee's first adverse outcome pathway (AOP) describing modes of actions leading to potentially heritable genomic damage is now online! This AOP focused on oxidative DNA damage and resulting mutations and chromosomal aberrations.  It is currently included in the OECD workplan and is ...

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Organocatalyst treatment improves variant calling and mutant detection in archival clinical samples

Nature Scientific Reports, 2022

Leah C. Wehmas, Charles E. Wood, Ping Guan, ...

Most archived biological tissue samples are preserved in formalin. Formalin fixation of biological samples damages nucleic acids and limits their use in future genomic analyses. Improved tools are needed to increase nucleic acid yield, reduce artifacts, and facilitate analysis and interpretation of genomic data, ...

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The benefits, limitations and opportunities of preclinical models for neonatal drug development

Disease Models & Mechanisms, 2022

Sarah Campion, Amy Inselman, Belinda Hayes, Costanza Casiraghi, ...

Increased research to improve preclinical models to inform the development of therapeutics for neonatal diseases is an area of great need. This article reviews five common neonatal diseases – bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, perinatal hypoxic–ischemic ...

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