Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 500 publications from HESI programs have been published in the last decade.

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Dose-response assessment of neuroactive botanical extracts and their bioactive constituents using microelectrode array (MEA) recordings in rat primary cortical neurons

Pharmaceutical Biology, 2025

van Kleef et al.

This research explores the neuroactivity of selected botanical extracts (including aconite, kava, kratom, and oleander) and their corresponding key constituents using a microelectrode array (MEA) platform. The study demonstrates the utility of MEA-based approaches for assessing dose-response and neuroactive potential ...

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Evaluation of Biomarkers to Detect Early Prothrombotic Imbalance in Rat Models of Hypercoagulability Induced by Thromboplastin Infusion and Hypofibrinolysis Induced by Tranexamic Acid

Toxicologic Pathology, 2025

Brooks et al.

In this new Toxicologic Pathology article from theĀ HESI Cardiac Safety Committeeā€™s Biomarkers Working Group, Brooks et al. systematically evaluate a suite of hemostatic biomarkers in rat models of tissue factorā€“driven hypercoagulability (thromboplastin infusion) and impaired fibrinolysis (oral tranexamic acid).

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