Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications

The Challenges of Predicting Drug-Induced QTc Prolongation in Humans

New publication in Toxicological Sciences by the HESI Cardiac Safety Committee shows that nonclinical models used to predict cardiac safety during drug development do not absolutely replicate the clinical conditions; however, best practices can be used to improve the nonclinical assay quality and achieve the ...

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An international scientific collaboration confirms the feasibility of a “direct” RT-qPCR assay which could increase global testing capacity of SARS-CoV-2

The continued waves of the COVID-19 pandemic have repeatedly strained public health systems’ capacity to provide efficient and actionable SARS-CoV-2 testing. To help address this challenge, the Propagate Network – a collaboration of public health and research laboratories from Brazil, Chile, France, Malawi, Nigeria, ...

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Utility of a next-generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide

The HESI Genetic Toxicology Technical Committee (GTTC) applies their systematic and flexible approach for assessing the risk of genetic damage due to exposure to chemical substances to etoposide, a drug used in certain types of cancer treatments, as a representative pharmaceutical case study.

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Incorporating Human Exposure Information in a Weight of Evidence Approach to Inform Design of Repeated Dose Animal Studies

Human health risks from chronic exposures to environmental chemicals are typically estimated from potential human exposure estimates and dose-response data obtained from repeated-dose animal toxicity studies. Various criteria are available for selecting the top (highest) dose used in these animal studies. For example, ...

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Opportunities and Challenges Related to Saturation of Toxicokinetic Processes: Implications for Risk Assessment

Top dose selection for repeated dose animal studies has generally focused on identification of apical endpoints, use of the limit dose, or determination of a maximum tolerated dose (MTD). The intent is to optimize the ability of toxicity tests performed in a small number of animals to detect effects for hazard identification. An ...

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