Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications

Use of Terrestrial Field Studies in the Derivation of Bioaccumulation Potential of Chemicals

Field-based studies are an essential component of research addressing the behavior of organic chemicals, and a unique line of evidence that can be used to assess bioaccumulation potential in chemical registration programs and aid in development of associated laboratory and modeling efforts.

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Use of the RISK21 Roadmap and Matrix: Human Health Risk Assessment of the Use of a Pyrethroid in Bed Netting

The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether additional refinement is required to obtain the necessary precision level for a decision regarding safety.

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Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy

The study (Pugsley et al., 2021. Journal of Pharmacological and Toxicological Methods) focused on the effects of high versus low dietary fat on the development of Type 2 diabetes in obese male ZDF rats, including biomarkers to detect early signs of hypercoagulability and vascular injury in the absence of overt thrombosis. Results ...

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Use of Trophic Magnification Factors and Related Measures to Characterize Bioaccumulation Potential of Chemicals

Recent technical workgroups have concluded that trophic magnification factors (TMFs) are useful in characterizing the bioaccumulation potential of a chemical, because TMFs provide a holistic measure of biomagnification in food webs.

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Using Exposure Bands for Rapid Decision Making in the RISK21 Tiered Exposure Assessment

The Health and Environmental Sciences Institute (HESI) Risk Assessment in the 21st Century (RISK21) Committee was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-based conceptual roadmap and risk matrix visualization tool, facilitating transparent ...

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Health and Environmental Sciences Institute (HESI)

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