Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Chapin RE, Alvey JD, Goldstein RA, Dokmanovich MG, Reagan WJ, ...
- HESI - Health and Environmental Sciences Institute
Serum Inhibin B was measured in two studies of known testis-toxic drug candidates.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Ziejewski MK, Vidal JD, Stanislaus D, Apostoli A, Chowdhury P, ...
- HESI - Health and Environmental Sciences Institute
In a repeat oral dose toxicity study, all of 16 male rats given 100 mg/kg/day GSK1322888 sustained testicular injury after 4 weeks of treatment; the findings were not reversible after 12 weeks off-dose.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Enright BP, Tornesi B, Lorenz H, Whitney K
- HESI - Health and Environmental Sciences Institute
This study was conducted as part of an ILSI-HESI consortium effort to assess the utility of circulating inhibin B as an early biomarker of testicular toxicity in rats.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013
Sonee M, Bogdan N, Hall L, Bryant S, Vinken P
- HESI - Health and Environmental Sciences Institute
This study was conducted as part of an ILSI-HESI International Life Sciences Institute-Health & Environmental Sciences Institute consortium effort to assess the utility of circulating Inhibin B as an early biomarker of Sertoli cell-specific testicular toxicity in rats.
Human and Experimental Toxicology, 2002
Holladay SD, Blaylock BL
- HESI - Health and Environmental Sciences Institute
The laboratory mouse has been the most extensively used model system for demonstrating postnatal immune deficits following perinatal immunotoxicant exposure.
Human and Experimental Toxicology, 2002
Hendrickx AG, Makori N, Peterson P
- HESI - Health and Environmental Sciences Institute
Macaques are well suited for preclinical testing of biopharmaceutics due to reproductive and developmental similarities with humans.
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