Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies

Neuromethods, 2019

He Z, Panos J, Raymick J, Konak T, Cui L, Miller DB, ...

Sampling and analysis of cerebrospinal fluid (CSF) is a common clinical practice used in the diagnosis, treatment, and prevention of neurological diseases. A similar interest is the sampling of CSF from rats to bridge the gap between bench-to-bedside work and to foster the development of new CSF biomarkers for clinical use. Here, ...

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A Multi-Laboratory Evaluation of a Common In Vitro Pepsin Digestion Assay Protocol Used in Assessing the Safety of Novel Proteins

Regulatory Toxicology and Pharmacology, 2004

Thomas K, Aalbers M, Bannon GA, Bartels M, Dearman RJ, Esdaile DJ, ...
  • HESI - Health and Environmental Sciences Institute

Evaluation of the potential allergenicity of proteins derived from genetically modified foods has involved a weight of evidence approach that incorporates an evaluation of protein digestibility in pepsin.

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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

International Journal of Toxicology, 2018

Emmanuel Boulay, Matthew M. Abernathy, Ray Chu, ...
  • HESI - Health and Environmental Sciences Institute

Results from this limited retrospective electrocardiogram analysis suggest that JTpca and Tpeca may discriminate selective IKr blockers and multichannel blockers and could be considered in the context of an integrated comprehensive proarrhythmic risk assessment.

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