Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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A Multi-Laboratory Evaluation of a Common In Vitro Pepsin Digestion Assay Protocol Used in Assessing the Safety of Novel Proteins

Regulatory Toxicology and Pharmacology, 2004

Thomas K, Aalbers M, Bannon GA, Bartels M, Dearman RJ, Esdaile DJ, ...
  • HESI - Health and Environmental Sciences Institute

Evaluation of the potential allergenicity of proteins derived from genetically modified foods has involved a weight of evidence approach that incorporates an evaluation of protein digestibility in pepsin.

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A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies

Neuromethods, 2019

He Z, Panos J, Raymick J, Konak T, Cui L, Miller DB, ...

Sampling and analysis of cerebrospinal fluid (CSF) is a common clinical practice used in the diagnosis, treatment, and prevention of neurological diseases. A similar interest is the sampling of CSF from rats to bridge the gap between bench-to-bedside work and to foster the development of new CSF biomarkers for clinical use. Here, ...

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A Framework for Cumulative Risk Assessment in the 21st Century

Critical Reviews in Toxicology, 2016

Moretto A, Bachman A, Boobis A, Solomon KR, Pastoor TP, Wilks MF, ...

The Health and Environmental Sciences Institute (HESI) has developed a framework to support a transition in the way in which information for chemical risk assessment is obtained and used. The approach is based on detailed problem formulation, where exposure drives the data acquisition process in order to enable informed ...

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A Different Approach to Validating Screening Assays for Developmental Toxicity

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2010

Daston GP, Chapin RE, Scialli AR, Piersma AH, Carney EW, ...
  • HESI - Health and Environmental Sciences Institute

There continue to be many efforts around the world to develop assays that are shorter than the traditional embryofetal developmental toxicity assay, or use fewer or no mammals, or use less compound, or have all three attributes.

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