Editorial published in JoVE by the HESI Cardiac Safety Committee
Comprehensive Collection of Current Methods for Contractility and Electrophysiology Recordings in Human Cardiac Cells
JoVE Journal, 2023
Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.
JoVE Journal, 2023
Editorial published in JoVE by the HESI Cardiac Safety Committee
Regenerative Medicine, 2023
HESI’s Cell Therapy-TRAcking, Circulation & Safety Technical Committee completed an international, multisite study to evaluate the sensitivity and reproducibility of the highly efficient culture (HEC) assay, an in vitro assay to detect residual undifferentiated human pluripotent stem cells (hPSCs) in cell therapy ...
Environmental Toxicology and Chemistry, 2023
A new critical review by Mitchell et al., published in Environmental Toxicology and Chemistry, examines the potential for expanding the use of New Approach Methodologies (NAMs) in endocrine activity testing and assessment.
Journal of Immunotoxicology, 2023
An insightful review by Kamperschoer et al. that provides an overview of the various methods for assessment of Cytotoxic T Lymphocytes (CTL) function in Non-Human Primates in the context of non-clinical safety assessment of immune-modulating therapeutic agents.
Nature Reviews Drug Discovery, 2023
The GTTC is pleased to share its newest publication, “Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing,” published in Nature Reviews Drug Discovery. The commentary highlights the potential applications, advantages and challenges associated with ...
Environmental and Molecular Mutagenesis, 2022
The Genetic Toxicology Technical Committee, under the Health and Environmental Sciences Institute, conducted a case study on 31 reference chemicals to evaluate the performance of IVIVE application to genotoxicity data.
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