PBPK Models Committee

PBPK Models Committee

Mission Statement

The committee aims to address key needs related to physiologically based pharmacokinetic (PBPK) modeling practices and applications that could facilitate use of PBPK models more consistently within the risk assessment context.

Committee Contacts

HESI Staff

Michelle Embry, PhD
membry@hesiglobal.org

Leadership Team

Anna Lowit, PhD
US Environmental Protection Agency

Paul Hinderliter, PhD
Syngenta

Members and Fact Sheet

Committee Publications

All Publications

PBPK Model Reporting Template for Chemical Risk Assessment Applications

Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment. While the development of PBPK models have grown steadily since their emergence, only a handful of models have been accepted to support regulatory purposes due to obstacles such as the lack of a standardized template for reporting PBPK analysis. Here, we expand the existing guidances designed for pharmaceutical applications by recommending additional elements that are relevant to environmental chemicals.

Read more

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