Professor Robert Barouki (Paris Descartes University) will present the 2019 HESI CITE Lecture, “Toxicology in the Era of the Exposome,” at EUROTOX on 10 September 2019 from 1:30 to 2:30 p.m. The HESI Combining Interdisciplinary and Translational Expertise (CITE) initiative is an ongoing outreach series that promotes discussion and progress on opportunities for, and challenges in, the application of interdisciplinary, multidisciplinary, and translational sciences to improve human and environmental health outcomes. Professor Barouki’s research focus is on the study of the dioxin receptor (AhR) in the fields of health and the environment. His clinical focus is on the identification of new metabolic biomarkers for rare diseases. Click here for the full EUROTOX program.
The HESI Microbiome Committee was referenced in Nature Reviews Drug Discovery (2018;17:383–384) for their work to address the state of the science and data gaps in gut microbiome research. The full article, titled “When Drugs Unintentionally Affect Gut Bugs,” is available here. Materials from the subsequent Microbiome Committee workshop are also available here.
The HESI CT-TRACS Committee is seeking participants in an international multi-site study to test in vitro methodologies for tumorigenicity assessment of cell therapy products (CTPs). The call was announced on 30 June 2019, as part of the Pluripotent Stem Cells Manufacturing Experts Panel Meeting in Los Angeles, California.
Click here to learn more about the study or to express interest. Please contact Lucilia Mouriès (email@example.com) with any questions.
The Immuno-safety Technical Committee (ITC) will hold a workshop in partnership with FDA/CBER in Silver Spring, Maryland, on 24–25 September 2019. The goal of this workshop is to discuss the preclinical and translational safety assessment of engineered T cell therapies. The workshop will focus on six topics, followed by an in-depth discussion:
Are you interested in hearing about new science to evaluate the bioaccumulation of organic chemicals? Would you like to learn how fish biotransformation can be integrated into bioaccumulation assessment? Do you want to hear about the new OECD in vitro biotransformation fish methods? Would you like to have training and experience using the Bioaccumulation Assessment Tool (BAT)? Plan to attend the HESI Bioaccumulation Committee Fish Biotransformation in Bioaccumulation Outreach Session on 4 October 2019 in Washington, DC. Registration is free! Contact Michelle Embry (firstname.lastname@example.org) for more details.
In the Northern Hemisphere where I live, summer can be a time of hot, sultry, and uncomfortable days. This year is no exception, with unusually high temperatures being recorded in the U.S. and Europe. For some, summer is a time for relaxing and holidays, but not so for HESI. There are several upcoming events of note. Michelle Embry, HESI Associate Director, will be presenting “Bridging the Gap with RISK 21: Risk Assessment in the 21st Century” at the Cellular and Molecular Mechanisms of Toxicity Gordon Research Conference on 14 August 2019. The HESI CITE initiative is sponsoring a lecture at EUROTOX on 10 September 2019; Professor Robert Barouki of Paris Descartes University will be presenting “Toxicology in the Era of the Exposome.” The FDA/CBER-HESI Workshop on the Safety Assessment of Engineered T Cell Therapies will be held 24-25 September 2019 in Silver Spring, Maryland. Information on the workshop can be found here. I hope you have the opportunity to attend one of these events and hear for yourself what HESI is doing to create science-based solutions for a healthier world.
Charlene McQueen, PhD