Events

Upcoming Events

Validation of New Approaches in Genetic Toxicology

Newark, Delaware, USA

Novel in vitro and in vivo assays have been developed to improve the reliability of tools employed for identification of genotoxic hazard. Several of the new assays can provide insight into mode-of-action (MoA). As emerging technologies generally used for evaluating human hazard and/or risk, these novel assays require rigorous evaluation and validation before use in a regulatory setting. Validating novel toxicology assaysis a continuing labor-intensive challenge. More specifically, many questions arise around choosing reference compounds, and comparing results against the current standard battery used for genotoxicity testing.

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2019 HESI Annual Meeting

Alexandria, Virginia, USA

Register now to celebrate 30 years of HESI science! This year’s program will bridge our past achievements and future plans to generate science for improved decision-making, enhanced human health and safety, and protected environments.

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				Thyroid Workshop_Logo1 (003)
	

Recent updates to OECD developmental/reproductive toxicology guidelines and other regulatory guidelines and guidance require the measurement of thyroid hormone levels in the blood of mammalian laboratory species during development.  Preliminary analyses indicate that there is a wide variability across laboratories in the methods being used to measure thyroid hormones in young rodents, as well as in the success of obtaining reliable data.  Even though publicly available regulatory guidelines and guidance address study design, they allow varied approaches to thyroid hormone measurement in rodents, and an optimal study design or logical approach to thyroid hormone testing in young rodents has not yet been established in a regulatory testing context.  Validity, accuracy, sensitivity and reproducibility of the assays are issues of concern.  It is not clear to what extent variability in the data can be attributed to methodological issues or to innate biological variability.

WORKSHOP AIMS

  1. Present the state-of-the-science on thyroid hormone assessments, specifically as it relates to preclinical methods and data collection, and identify gaps and knowledge as it relates to regulatory DART testing,
  2. Provide clarification and guidance regarding the collection (timing and methods), assessment (standardization and validation), and interpretation of thyroid hormone data (as it relates to adversity) for regulatory toxicology and risk assessment,
  3. Discuss and come to consensus on recommendations on how to improve data interpretation/understanding of thyroid changes and their relationship to adverse outcomes
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WORKSHOP AGENDA

Click here to download the draft workshop agenda.

REGISTRATION DETAILS

Click here to register for the Thyroid Hormone Assessment Workshop. Registration will close on Friday, April 19 or when we reach maximum capacity.

Questions? Contact Connie Chen (cchen@hesiglobal.org) for more information.

HOTEL INFORMATION

Washington Plaza Hotel
10 Thomas Circle NW
Washington, DC 20005 Room rate: $279 per night
Deadline to book room: Friday, April 5, 2019
Click here to reserve your room within the room block or call 1-800-424-1140 and reference the HESI DART Committee Spring Meeting. Nearby Hotels
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Related Events

2019 Safety Pharmacology Society (SPS) Annual Meeting
Centre de Convencions Internacional de Barcelona
Barcelona, Spain
September 23–26, 2019

For more information regarding the agenda and to register for the meeting, please visit the website.