Transcriptomic Biomarker for Genotoxicity Assessment of Pharmaceuticals and Environmental Chemicals

The HESI eSTAR Committee will be presenting as part of the Physicians Committee for Responsible Medicine webinar series called "Tomorrow's Data, Today: Sunsetting the 2-year Carcinogenicity Assay."

As part of the series, Connie Mitchell (HESI) will present a talk titled "Transcriptomic Biomarker for Genotoxicity Assessment of Pharmaceuticals and Environmental Chemicals."

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Objectives:

• Understanding the process of developing an in vitro transcriptomic biomarker
• Discuss the ongoing validation process to gain regulatory acceptance

Speaker Bio:

Connie Mitchell is a Scientific Program Manager at the Health and Environmental Sciences Institute (HESI), a science non-profit based in Washington, DC, USA. Prior to joining HESI in early 2020, she was an ORISE Fellow at the US Environmental Protection Agency working on chemical prioritization under the Toxic Substances Control Act. She completed her graduate studies in Environmental Toxicology at the University of California Riverside. There she investigated flame retardant-induced developmental toxicity. At HESI, Connie manages the Systems Toxicological Committee (eSTAR), which is a multi-partite, multi-stakeholder international group of experts to develop and deliver innovative toxicology approaches for risk assessment. As a Scientific Program Manager, she provides scientific, strategic, and management support to collaborative scientific committees involving academic, government, nonprofit, and private sector scientists. She also co-manages other projects related to toxicology and risk assessment, including the Next Generation Ecological Risk Assessment Committee, and the Botanical Safety Consortium. She has authored or co-authored 14 peer-reviewed papers and has presented at numerous national and international scientific meetings on topics ranging from toxicology, risk assessment, and new approach methodologies.

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