The Quantitative Subgroup will be the focus of the IVGT in 2010 and beyond. This Subgroup also has several smaller groups, to assist in the objective of gathering/analyzing dose-response data to support the decision tree. This includes a collaborative project with Health Canada, development of a relational database to house dose-response genetic toxicology data, and a Pig-a Interest Group to provide dose-response data for that endpoint.
The Improving Existing Assays Subgroup is new for 2010, and has the following short-term goals: 1) evaluate the reduction of the maximum concentration tested in in vitro mammalian cell tests, and 2) to confirm identity and quality of cell lines commonly utilized in genotoxicity testing. These objectives were identified as “needs” by the IWGT this past summer. This was discussed at an IVGT meeting held in Basel, Switzerland on August 19, 2009.
The objective of this new Subgroup for 2010 is to plan and execute a 2nd IVGT Workshop: “Adoption of alternative in vitro/ex vivo models for genetic toxicity testing.” This was discussed at an IVGT meeting held in Basel, Switzerland on August 19, 2009. This objective was discussed in the context of the New/Emerging Technologies Working Group fulfilling its original objective upon publication of the May 2008 workshop proceedings. The formation of a new Subgroup to evaluate alternative models outside the usual realm of models used for genotoxicity assessment was thought necessary since the New/Emerging Technologies Working Group will be sunset.
This potential project is currently being surveyed among IVGT sponsors. Please return the previously distributed survey if you have not yet done so. Recently, sponsors of the HESI Immunotoxicology Technical Committee (ITC) have expressed interest in a potential workshop on the immunotoxicity of nanomaterials/nanoparticles, since the HESI Technical Committee on the Safety of Nanomaterials was sunsetted in 2009. One suggestion is to host a joint workshop (IVGT and ITC) on the genotoxicity and the immunotoxicity of nanomaterials/nanoparticles. If the IVGT and ITC decide that such a workshop falls outside the scope of these committees, the workshop might be pursued as a “Resources at Initiation” (RAI) project, whereby funding for the workshop could be provided by the committees and by interested parties. The workshop then would be outside the purview of the IVGT and ITC, and would directly engage those parties specifically interested in the workshop.