PATB Committee Protein Toxins Workshop

  • Start Date/Time :
  • End Date/Time :
  • Location : Virtual workshop, hosted by the HESI PATB Committee

The HESI Protein Allergens, Toxins, and Bioinformatics (PATB) Committee is co-hosting a virtual workshop in collaboration with the Society of Toxicology (SOT) Food Safety Specialty Section titled “From Protein Toxins to Applied Toxicological Testing” in the context of safety assessment of novel foods and feeds. The virtual workshop will take place on 21–22 October 2020 from 9:00 AM to 1:00 PM EST each day and is open to all interested participants. It will cover the state of the science in protein toxins biology (structure, activity, MOA, etc.), current bioinformatics approaches used to identify and characterize protein toxins, with the ultimate goal to leverage computational biology and in silico approaches for determining the potential of a protein to present toxic properties.

The Protein Toxins Workshop will serve the dual purpose of learning about the advances in protein toxin research presented by recognized international academic experts in the field and assessing the translation of knowledge to practical applications (e.g., into weight-of-evidence approaches for the safety assessment of biotechnology products; relevance, applicability, and limitations of existing protein toxin databases and tools for risk assessment). The desired outcome of this event is to help inform the development of contemporary and scientifically robust approaches for the identification and classification of potential toxicity risk in novel proteins.


  • Date: Wednesday, 21 October 2020 – Thursday, 22 October 2020
  • Time: 9:00 AM – 1:00 PM EST

Workshop Publication

“From Protein Toxins to Applied Toxicological Testing” virtual workshop identifies the need for a bioinformatic framework to assess novel food protein safety. Bauman PA, Doxey AC, Eberini I, Islamovic E, Jungo F, Kessenich C, Kough J, Krishanh M, Palazzolo L, Privalle L, Rodriguezi CE, Satchell KJF, Silvanovich A, Mouriès LP. Regulatory Toxicology and Pharmacology. June 2022.

Protein Toxins Workshop Speakers

  • Andrew Doxey, PhD

    University of Waterloo

    Read Bio
  • Florence Jungo, MS

    Swiss Institute of Bioinformatics / SwissProt

    Read Bio
  • Anna Lanzoni, PhD, DVM

    European Food Safety Agency

    Read Bio
  • Ray Matulka, PhD

    Burdock Group

    Read Bio
  • Luca Palazzolo, PhD

    University of Milano

    Read Bio
  • Laura Privalle, PhD

    BASF Plant Science

    Read Bio
  • Karla Satchell, PhD

    Northwestern University

    Read Bio
  • Andre Silvanovich, PhD

    Bayer CropScience

    Read Bio

Protein Toxins Workshop Program

Wednesday, 21 October 2020

Session Chairs: Dr. Emir Islamovic (BASF Plant Science and HESI PATB Committee Co-Chair) and Dr. Ray Matulka (Burdock Group and SOT member)

Opening Session
9:00 AM – Welcome and Opening Remarks (Dr. Lucilia Mouriès, HESI, and Session Chairs)
9:15 AM – Context and Background Presentations: From Protein Toxins to Biotechnology Products (HESI PATB Committee members and  SOT FSSS speakers)

  • Regulatory Approvals for Biotechnology Products: Dr. Laura Privalle, BASF Plant Science, HESI PATB Committee Protein Toxins Task Force (download presentation)
  • Allergen and Toxin Databases: Dr. Andre Silvanovich, Bayer Crop Science, HESI PATB Committee member (download presentation)
  • Essential Components of a Regulatory Safety Assessment for a Protein Based, Novel Food Ingredient: Dr. Ray Matulka, Burdock Group, SOT member

10:45 AM – Break

Keynote Presentation (11:00 AM – 12:00 PM EST)
11:00 AM – Overview of Protein Toxins Biology and the Vibrio MARTX Toxins: Prof. Karla Satchell, Northwestern University
12:00 PM – Session-wide Q&A and discussion
1:00 PM – Adjourn

Thursday, 22 October 2020

Session 2: Bioinformatics and Computational Biology in Protein Toxins Research
Session Chairs: Dr. Colton Kessenich (Bayer Crop Science and HESI PATB Committee Protein Toxins Task Force) and Dr. Mansi Krishan (BD, Immediate Past President, and SOT Food Safety Specialty Section 2020-2021)

9:00 AM – Opening Remarks (Session Chairs)
9:10 AM – Protein Toxins: Overview of Databases and Other Resources: Dr. Florence Jungo, Swiss Institute of Bioinformatics / SwissProt (download presentation)
9:50 AM – Discovery of Novel Bacterial Toxins Through Bioinformatic Data Mining: Prof. Andrew Doxey, University of Waterloo
10:30 AM – Break
10:45 AM – Insights into the EFSA Protein Risk Assessment: In Silico Tools: Dr. Anna Lanzoni, European Food Safety Agency (download presentation)
11:15 AM – Protein Toxicity: An Integrated In Silico Pipeline: Dr. Luca Palazzolo, University of Milano (download presentation)
11:45 AM – Session-wide Q&A and discussion
12:30 PM – Summary of Day 1 and Day 2
1:00 PM – Adjourn


Please see the full, detailed workshop program here as well as suggested reading materials here.
For more information, please contact the PATB Committee’s Senior Scientific Program Manager, Dr. Lucilia Mouriès, at

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