The HESI Protein Allergens, Toxins, and Bioinformatics (PATB) Committee is co-hosting a virtual workshop in collaboration with the Society of Toxicology (SOT) Food Safety Specialty Section titled “From Protein Toxins to Applied Toxicological Testing” in the context of safety assessment of novel foods and feeds. The virtual workshop will take place on 21–22 October 2020 from 9:00 AM to 1:00 PM EST each day and is open to all interested participants. It will cover the state of the science in protein toxins biology (structure, activity, MOA, etc.), current bioinformatics approaches used to identify and characterize protein toxins, with the ultimate goal to leverage computational biology and in silico approaches for determining the potential of a protein to present toxic properties.
The Protein Toxins Workshop will serve the dual purpose of learning about the advances in protein toxin research presented by recognized international academic experts in the field and assessing the translation of knowledge to practical applications (e.g., into weight-of-evidence approaches for the safety assessment of biotechnology products; relevance, applicability, and limitations of existing protein toxin databases and tools for risk assessment). The desired outcome of this event is to help inform the development of contemporary and scientifically robust approaches for the identification and classification of potential toxicity risk in novel proteins.
Wednesday, 21 October 2020
Session Chairs: Dr. Emir Islamovic (BASF and HESI PATB Committee Co-Chair) and Dr. Ray Matulka (Burdock Group Consultants and SOT member)
9:00 AM – Welcome and Opening Remarks (Dr. Lucilia Mouriès, HESI, and Session Chairs)
9:15 AM – Context and Background Presentations: From Protein Toxins to Biotechnology Products (HESI PATB Committee members and SOT FSSS speakers)
10:45 AM – Break
Keynote Presentation (11:00 AM – 12:00 PM EST)
11:00 AM – Overview of Protein Toxins Biology and the Vibrio MARTX Toxins: Prof. Karla Fullner Satchell, Northwestern University, USA
12:00 PM – Session-wide Q&A and discussion
1:00 PM – Adjourn
Thursday, 22 October 2020
Session 2: Bioinformatics and Computational Biology in Protein Toxins Research
Session Chairs: Dr. Colton Kessenich (Bayer and HESI PATB Committee Protein Toxins Task Force) and Dr. Mansi Krishan (BD, Immediate Past President, and SOT Food Safety Specialty Section 2020-2021)
9:00 AM – Opening Remarks (Session Chairs)
9:10 AM – Protein Toxins: Overview of Databases and Other Resources: Dr. Florence Jungo, Swiss Institute of Bioinformatics / SwissProt, Switzerland
9:50 AM – Discovery of Novel Bacterial Toxins Through Bioinformatic Data Mining: Prof. Andrew Doxey, University of Waterloo, Canada
10:30 AM – Break
10:45 AM – Insights into the EFSA Protein Risk Assessment: In Silico Tools: Dr. Anna Lanzoni, European Food Safety Agency, Italy
11:15 AM – Protein Toxicity: An Integrated In Silico Pipeline: Dr. Luca Palazzolo, University of Milano, Italy
11:45 AM – Session-wide Q&A and discussion
12:30 PM – Summary of Day 1 and Day 2
1:00 PM – Adjourn
Please see the full, detailed workshop program here as well as suggested reading materials here. For more information, please contact the PATB Committee’s Senior Scientific Program Manager, Dr. Lucilia Mouriès at firstname.lastname@example.org.