International Bioinformatics Workshop

The purpose of the workshop is to evaluate the current methodologies used for identifying similarities to known allergens and toxins. This workshop is a part of the committee’s broader activities that are focused on advancing the scientific understanding of the relevant parameters for characterizing the allergenic potential of novel proteins and biotechnology products.  The primary deliverable from this workshop will be a comprehensive manuscript that will summarize the discussions and key findings from the workshop.

Workshop Materials

Workshop Agenda (PDF)

Workshop Manuscript Outline (PDF)

Confirmed Workshop Participants  (PDF)

Workshop Focus Questions (PDF)

Manuscript Data Abstracts

• Allergy Assessment of Novel Proteins Using Short Amino Acid Sequence Searches
• Computational Tools for Allergenicity Prediction in SDAP
• Contribution of CCD’s on RAST scores and an inhibition RAST with anti HRP (CCD) antibodies as a possible way to prevention of false-positive diagnostic results
• Evaluation of the search for 6 contiguous amino acids match and 35% or more homology over 80 amino acids – guideline in FAO/WHO Expert Consultation (2001)
• Improvement of ELISA method for antigen-specific IgE in human sera
• Investigation of the Similarity of Allergens within the FARRP5 Dataset: Implications for the Current FAO/WHO Similarity Threshold
• FARRP Common allergen database update

Manuscript Editorial Board

Workshop Plenary Presentations

• Workshop Welcome and HESI Overview
• PATC Overview and Workshop Goals / Objectives
• Food Allergy Review
• Assessment Methodology for Evaluating Novel Proteins
• Introduction to Bioinformatics
• Allergen Databases
• Structural Biology
• IgE Cross-Reactivity
• IgE Binding Data and its Utility in Bioinformatics
• Allergen Specific IgE Testing in the Diagnosis of Food Allergy
• Serum IgE Testing
• Final Workshop Manuscript

Further Information

Inquiries regarding the HESI International Bioinformatics Workshop should be directed to Karluss Thomas (kthomas@ilsi.org) or Eric Moore (emoore@ilsi.org).