GTTC Quantitative Analysis Working Group Workshop

This workshop is a pre-GTTC Annual Meeting workshop to provide extra time to discuss 2020-21 Quantitative Analysis Working Group activities, as well as emerging challenges and upcoming milestones. The presentations will collectively cover a variety of topics and issues pertaining to the refinement of quantitative methods for interpretation of genetic toxicity dose-response data in a risk assessment context.

The virtual workshop is open to GTTC Committee participants only. Click here to learn more about the HESI GTTC Committee.

Agenda

Welcome & Opening Remarks
Paul White, Health Canada, and E'Lissa Flores, HESI

Topic 1: Determination of Human Exposure Limits for Mutagenic Alkylnitrosamines
George Johnson, Swansea University, Swansea, UK

Topic 2: CES (Critical Effect Size) Values for In Vivo Mutagenicity Endpoints
Guangcho Chen, RIVM, Bilthoven, The Netherlands

Break

Topic 3: Inter-Individual Variability in Human Sensitivity to Environmental Mutagens
Paul White, Health Canada (Intro)

Part 1: Results from Comparative Analyses of In Vitro Dose Response Data
Lauren Gallant, University of Ottawa, Ottawa, Canada

Part 2: Results from Comparative Analyses of Human DNA Repair Capacity (DRC)
Madison Bell, University of Ottawa, Ottawa, Canada

Break

Topic 4: GToxPi - A Multi-Endpoint Data Synthesis and Visualization Tool
Steve Detringer, Litron Laboratories, Rochester, New York, USA

Closing Remarks
Andreas Zeller, Hoffman-La Roche