Genomics from Formalin-Fixed Paraffin Embedded Tissue Samples: Methods and Lessons Learned for Risk Assessment

Please join us for an upcoming webinar, organized by the HESI Emerging Systems Toxicology for the Assessment of Risk (eSTAR) Committee:

Dr. Leah Wehmas (United States Environmental Protection Agency) will present work from the eSTAR FFPE Project.

Abstract: Formalin-fixed paraffin-embedded (FFPE) tissues provide an important resource for toxicogenomic research. FFPE tissues samples often represent the only remaining biological samples from important chemical toxicity assessments. However, use of these samples for genomic analysis has been limited due to formalin-fixation related damage to nucleic acids. Improved tools are needed to increase nucleic acid yield, reduce artifacts, and facilitate analysis and interpretation of genomic data (RNA and DNA) from FFPE tissue samples. This webinar will highlight the work of the HESI eSTAR FFPE Project in these areas, including methods to improve variant calling and mutant detection of FFPE tissue samples, and case studies using gene expression analysis from up to 25 year old FFPE tissue samples to quantitatively investigate chemical mode of action and risk.

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