BENCHMARK DOSE MODELLING FOR RISK ASSESSMENT: BUILDING A PATH TOWARD HARMONIZATION

Participation: Open to the public including regulatory scientists, researchers, industry professionals, and those interested in learning about applications of BMD. All talks will be recorded and made available after the sessions.

Registration: Click here to register
Agenda: Download here

Overview
HESI Global is hosting a webinar series on Benchmark dose modeling (BMD). BMD is increasingly used in risk assessment, yet differences in methods, tools, and key concepts continue to limit consistency across sectors and regulatory frameworks. This webinar brings together experts across regions from regulatory agencies, academia, and industry to share global perspectives on BMD modeling. Cross-sector perspectives are brought together to examine current practices, share lessons learned, and identify opportunities for greater alignment supporting more consistent and harmonized application of BMD approaches.

Day 1: Foundations and Applications of BMD
Day 1 will provide a shared foundation in BMD modeling, including the evolution from NOAEL-based approaches to BMD and its role in modern risk assessment. Speakers will cover core concepts and practical applications across a range of endpoint types, including repeat-dose toxicity, genetic toxicology, developmental and reproductive studies, ecotoxicology, omics, and epidemiology. Interactive discussions will highlight common challenges and areas of convergence.

Day 2: Cross-Sector Challenges and Paths Toward Harmonization
Day 2 will focus on real-world challenges in applying BMD modeling across sectors such as agrochemicals, pharmaceuticals, industrial chemicals, food and consumer products. Regulatory and industry perspectives will examine issues including study design, data quality and availability, model and software selection, and shared conceptual frameworks. Participants will engage in live polling and panel discussions to help identify priority areas where harmonization efforts may be most impactful.

Outcomes
The webinar will set the stage for follow-on discussions aimed at prioritizing feasible harmonization topics and identifying next steps for collaborative efforts across sectors.

Planning Committee
Dr. Alan Boobis – Imperial College London
Dr. Felix Kluxen - BASF
Dr. Sheila Logan – APVMA (Retired)
Dr. Andy Nong – Health Canada
Emily Scorgie - Syngenta
Philip Villanueva – US EPA
Andrew Williams – Health Canada

Contact Information
If you have questions about this webinar series, please contact the HESI staff listed below.
Claire O’Brien – cobrien@hesiglobal.org
Raechel Puglisi – rpuglisi@hesiglobal.org
Michelle Embry – membry@hesiglobal.org