3rd International Conference Genotoxic Compounds

HESI eSTAR and GTTC committee members Carol Yauk (University of Ottawa), Francesco Marchetti (Health Canada), and Paul White (Health Canada) will present at the 3rd International Conference Genotoxic Compounds, a virtual event taking place 13 and 14 February 2025.

Thursday 13 February 2025

Paul A. White, Health Canada, Canada. Update on HESI (Health and Environmental Sciences Institute) and the activities of the GTTC’s (Genetic Toxicology Technical Committee) quantitative analyses workgroup.

Francesco Marchetti, Health Canada, Canada. Development of test methods and guidelines The coming revolution: application of error corrected next generation sequencing (ecNGS) to quantify and characterise mutations.

• ecNGS: Promises and challenges for genotoxicity and cancer risk assessment
• How Duplex Sequencing is being used to advance mutagenesis and carcinogenesis research

Carole Yauk, University of Ottawa, Canada. Advances in the use of transcriptomic biomarkers for genotoxicity assessment: From validation to implementation.

• The journey of the TGx-DDI transcriptomic biomarker as it proceeds through the US FDA qualification process
• State of the science of applying TGx-DDI in integrated testing for qualitative and quantitative applications
• Work to expand the context of use and define suitable application domains (beyond TK6 cells)

Register here