Next Generation Ecological Risk Assessment

Note: As of 2022, the former Animal Alternatives in ERA and Bioaccumulation Committees have merged to form the Next Generation ERA Committee

Mission Statement

To develop, refine, and communicate the scientific tools and approaches needed to support ecological risk assessment around the globe, with a focus on alternative, non-animal testing methods.

Working Groups

  • Alternatives to Chronic Fish Testing

    This group held two workshops in Q4 of 2023. Key consensuses from the workshop included the need for a coordinated network of experts interested in ecotoxicology and a movement from a 1:1 replacement of existing methods towards an integrative assessment strategy. To support this, the working group has been coordinating the Innovate EcoTox workshop in 2025, and developing a plan for illustrative, integrative case studies.

  • Avian Bioaccumulation and Biotransformation

    The committee has funded a multi-year project at the University of Saskatchewan to develop a bird in vitro biotransformation assay. The advisory team assisted in selecting chemicals to evaluate the developed methods and has been meeting regularly with the research team at the University of Saskatchewan. This work was presented by University of Saskatchewan colleagues at the Canadian Ecotoxicity Workshop 2023, SETAC North America 44th Annual Meeting, and SETAC Europe 34th Annual Meeting.

  • Bioaccumulation: State of the Science Outreach

    In Q3 of 2023, a small sub-team submitted an OECD case study on the use of Integrated Approaches for Testing and Assessment (IATA) for bioaccumulation. This case study aims to guide the collection, generation, evaluation, and weighting of various types of bioaccumulation data to enhance the prediction of chemicals’ ecological effects. The OECD has recently published the IATA, which is available here.

  • Bird Behavior

    This group is investigating the influence of bird life history traits on chemical exposure. A manuscript on the current state of the science in this field is in progress, and a database of bird life history traits has been developed.

  • Ecotoxicology Endocrine Toolbox

    This team, a collaboration between HESI and NC3Rs, is focused on assessing available in vitro/in silico methods (new approach methodologies [NAMs]) to evaluate chemicals that may act via an endocrine pathway in fish and amphibians. Within this effort, several sub-groups focus on related supporting topics:

    • NAM evaluation & case study development
    • in vivo endocrine disrupting chemical (EDC) tests in fish and amphibians, focusing on analysis of historical control data
    • Maximum Tolerated Dose (MTD) project
  • EnviroTox Database and Tools / Ecological Threshold of Toxicological Concern (ecoTTC)

    This group is tasked with developing a strategy to update and augment the EnviroTox database (https://envirotoxdatabase.org) and refine and further develop applicable tools. They are also scoping future work, including mode of action classifications, acute-to-chronic ratios for extrapolation, and understanding water quality criteria values globally.

  • Fish Bioaccumulation and Biotransformation

    This group is working on scoping the needs & advancements in fish toxicokinetics and PBPK models. As part of this effort, they are mapping out available bioaccumulation methods/models to organize and present PBPK models in a more transparent and accessible way for end users.

  • Past Working Groups

    Effluent Assessment: This team is working to engage with various stakeholders about current effluent testing approaches and needs within North America, to identify the opportunities and limitations related to alternative methods. Ongoing work is focused on the development of informational webinars and information sharing across stakeholders to identify suitable next steps.

HESI Staff

Committee Events

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Committee Publications

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Evaluation of in vivo fish and amphibian endocrine test guideline assays: current status and future needs

Environmental Toxicology and Chemistry, 2025

Burden et al.

The HESI Global Next Generation Ecological Risk Assessment Committee is proud to share a new publication in collaboration with the UK's NC3Rs: “Evaluation of in vivo fish and amphibian endocrine test guideline assays: current status and future needs” (Environmental Toxicology and Chemistry, Burden et al., ...

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Control Performance of Amphibian Metamorphosis Assays with Xenopus laevis

Regulatory Toxicology and Pharmacology, 2025

Wheeler et al.

This study addresses variability challenges in the Amphibian Metamorphosis Assay (AMA), a widely used assay to detect the endocrine-disrupting effects of chemicals on the thyroid system. By analyzing data from 52 studies across seven laboratories, the paper highlights how variability in controls affects the assay's ...

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A Critical Review of Bioaccumulation and Biotransformation of Organic Chemicals in Birds

Reviews of Environmental Contamination and Toxicology, 2022

Kuo DTF, Rattner BA, Marteinson SC, Letcher R, Fernie KJ, Treu G, ...

A literature review of bioaccumulation and biotransformation of organic chemicals in birds was undertaken, aiming to support scoping and prioritization of future research. The objectives were to characterize available bioaccumulation/ biotransformation data, identify knowledge gaps, determine how extant data can be ...

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An examination of historical control histopathology metadata from 51 Amphibian Metamorphosis Assays

Critical Reviews in Toxicology, 2022

Wolf JC, Bejarano AC, Fort DJ and Wheeler JR

The Amphibian Metamorphosis Assay (AMA) is used to identify substances that potentially interfere with the normal function of the hypothalamic-pituitary-thyroid (HPT) axis. The current investigation reviewed 51 AMA experiments conducted at 7 different laboratories in Europe and North America. Diagnostic approaches to ...

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Center for Environmental & Ecological Health

The Next Generation Ecological Risk Assessment Committee is part of the Center for Environmental & Ecological Health. This HESI Center serves as a focal point for staff to share strategic approaches, scientific developments, management best practices and innovations with other related HESI committees.

Other Committees in the Center for Environmental & Ecological Health:

For questions about the Center contact:
Center Director: Michelle Embry
Center Advisor: Sandrine Deglin

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-8403

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