Multi-Component Substances (MCS) and UVCBs Subcommittee

Multi-Component Substances (MCS) and UVCBs Subcommittee

Mission Statement

To develop a tiered approach to MCS/UVCB ecological risk assessment.

 

Objectives:

  • Developing tools and identifying data gaps in support of risk assessment
  • Identify and develop models and methods (practical / workable)
  • Develop best practices and guidance
  • Engage with multi-stakeholder collaborative research projects

Committee Contacts

HESI Staff

Michelle Embry, PhD
membry@hesiglobal.org

 Sandrine Deglin PhD
sdeglin@hesiglobal.org

Members and Fact Sheet

Committee Publications

All Publications

Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs)

Substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs) pose unique risk assessment challenges to regulators and to product registrants. These substances can contain many constituents, sometimes partially unknown and/or variable, depending on fluctuations in their source material and/or manufacturing process. International regulatory agencies have highlighted the difficulties to characterize UVCBs and to assess their toxicity and environmental fate. Based on the output of a 2016 workshop, this Critical Review examines current practices for UVCB risk assessment and reveals a need for a multi‐pronged and transparent approach integrating whole‐substance and constituent‐based information.

Read more

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