Translational Biomarkers of Neurotoxicity (NeuTox) Committee

Mission Statement

The committee’s mission is to identify biomarkers for improving the prediction of neurotoxicity and seizurogenic compounds using microelectrode array (MEA).

Working Groups

  • Translational Biomarkers of Neurotoxicity

    This group is working toward identifying biomarkers of improving the prediction of neurotoxicity and identifying correlations in behavioral, imaging, and neuropathological endpoints. A phase 2
    study was launched to validate a set of biomarkers of neurotoxicity.

  • Microelectrode Array Subteam

    This group is working toward characterizing the predictivity of seizurogenic activity using MEA technology. A final analysis of data generated from a multi-site study is expected by early 2023.

  • Think Tank Planning Subteam

    A subteam was formed to plan a small Think Tank workshop where participants will
    discuss possible new areas of focus and next steps.

HESI Staff

Leadership Team

  • Tucker Patterson, PhD

    U.S. Food & Drug Administration

  • Ruth Roberts, PhD, FRSB, FRCPath

    ApconiX, Ltd.

Committee Publications

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Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward

Toxicological Sciences, 2015

Roberts RA, Aschner M, Calligaro D, Guilarte TR, Hanig JP, ...

Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking. There is a need for more sensitive and specific biomarkers of neurotoxicity that can help diagnose and predict neurotoxicity that are relevant across animal models and translational from ...

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Drug Discovery and Development: Biomarkers of Neurotoxicity and Neurodegeneration

Experimental Biology and Medicine, 2018

Walker AL, Imam SZ, & Roberts RA

Attrition in drug discovery and development remains a major challenge. Safety/toxicity is the most prevalent reason for failure with cardiovascular and CNS toxicities predominating. Non-invasive biomarkers of neurotoxicity would provide significant advantage by allowing earlier prediction of likely neurotoxicity in ...

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Changes in the Metabolome and microRNA Levels in Biological Fluids Might Represent Biomarkers of Neurotoxicity: A Trimethyltin Study

Experimental Biology and Medicine, 2017

Imam SZ, He Z, Cuevas E, Rosas-Hernandez H, Lantz SM, Sarkar S, ...

Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at ...

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Can We Panelize Seizure?

Toxicological Sciences, 2020

Roberts R, Authier S, Mellon D, Morton M, Suzuki I, Tjalkens RB, ...

Seizure liability remains a significant cause of attrition in drug discovery and development, leading to loss of competitiveness, delays and increased costs. Current detection methods rely on observations made in in vivo studies intended to support clinical trials, such as tremors or other abnormal movements. These signs ...

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A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies

Neuromethods, 2019

He Z, Panos J, Raymick J, Konak T, Cui L, Miller DB, ...

Sampling and analysis of cerebrospinal fluid (CSF) is a common clinical practice used in the diagnosis, treatment, and prevention of neurological diseases. A similar interest is the sampling of CSF from rats to bridge the gap between bench-to-bedside work and to foster the development of new CSF biomarkers for clinical use. Here, ...

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                            [compare_key] => =
                            [alias] => mt3
                            [cast] => CHAR
                        )

                    [mt4] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2010-12-31
                            [compare] => <
                            [compare_key] => =
                            [alias] => mt4
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id) INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )  INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )  INNER JOIN wp_postmeta AS mt2 ON ( wp_posts.ID = mt2.post_id )  INNER JOIN wp_postmeta AS mt3 ON ( wp_posts.ID = mt3.post_id )  INNER JOIN wp_postmeta AS mt4 ON ( wp_posts.ID = mt4.post_id )
					WHERE 1=1  AND ( 
  wp_term_relationships.term_taxonomy_id IN (810)
) AND ( 
  wp_postmeta.meta_key = '_ilsi_date' 
  AND 
  ( 
    ( mt1.meta_key = '_ilsi_date' AND mt1.meta_value <= '2050-01-01' ) 
    AND 
    ( mt2.meta_key = '_ilsi_end_date' AND mt2.meta_value <= '2050-01-01' ) 
    AND 
    ( mt3.meta_key = '_ilsi_date' AND mt3.meta_value BETWEEN '2010-01-01' AND '2010-12-31' ) 
    AND 
    ( mt4.meta_key = '_ilsi_date' AND mt4.meta_value < '2010-12-31' )
  )
) AND ((wp_posts.post_type = 'event' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 0, 6
				
    [posts] => Array
        (
        )

    [post_count] => 0
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 0
    [max_num_pages] => 0
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 1
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 7c284c9b5baa93d2ae4ad41e863e99f7
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-8403

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