Journal of Pharmacological and Toxicological Methods, 2010
Pettit SD, Berridge B, Sarazan RD
Cardiovascular safety concerns are a significant cause of attrition in the development of new drugs (Lasser et al., 2002).
Journal of Pharmacological and Toxicological Methods, 2009
Trepakova ES, Koerner J, Pettit SD, Valentin JP
Drug-induced ventricular arrhythmia and Torsades de Pointes remain a serious public health issues in bringing safe new pharmaceuticals to the market place.
International Journal of Toxicology, 2018
Emmanuel Boulay, Matthew M. Abernathy, Ray Chu, ...
Results from this limited retrospective electrocardiogram analysis suggest that JTpca and Tpeca may discriminate selective IKr blockers and multichannel blockers and could be considered in the context of an integrated comprehensive proarrhythmic risk assessment.
Journal of Pharmacological and Toxicological Methods, 2013
Pierson JB, Berridge BR, Brooks MB, Dreher K, Koerner J, ...
The evaluation of cardiovascular side-effects is a critical element in the development of all new drugs and chemicals.
Journal of Pharmacological and Toxicological Methods, 2017
Michael K. Pugsley, Brian Guth, AlanY. Chiang, ...
The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety testing for years, the non-clinical assessment of drug effects on myocardial contractility is used less frequently with ...
Clinical Chemistry, 2008
Apple FS, Murakami MM, Ler R, Walker D, York M, ...
Information is needed regarding analytical characteristics of cardiac troponin (cTn) assays used in preclinical studies.
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