Cardiac Safety Committee

Mission Statement

The mission of the HESI Cardiac Safety Committee is to improve public health by reducing unanticipated cardiovascular-related adverse effects from drugs or chemicals, and to develop innovative approaches to support early detection and prediction as well as improved understanding of cardiovascular toxicology and pathobiology.

Cardiac Safety Committee Early Career Seminar Award Series

The HESI Cardiac Safety Committee is excited to announce the winners for the committee’s new Early Career Seminar Award Series. This award offers an opportunity for postdocs and early career scientists to share their research, learn from, and network with experts in the toxicology and safety pharmacology fields from academia, regulatory agencies, and pharmaceutical companies. Awardees receive a $500 USD award and are invited to present their research on a public webinar with Cardiac Safety Committee members and other invited guests.

Three awardees were selected for this inaugural Seminar Series:

  • Dr. Julia Hotek, Merck (see event details)
  • Dr. Arvin Soepriatna, Brown University
  • Dr. Shagun Krishna, NTP-NIEHS

Working Groups

  • Stem Cell Working Group

    This group is working to understand and characterize use of stem cell–derived cardiomyocytes in cardiac safety assessments. An article that included best practices for use of stem cell cardiomyocytes in cardiac safety assessments was published in Regulatory Toxicology and Pharmacology. A new group is planning a study to explore in vitro assay ability to detect cardiotoxicity.

    Leadership Team:
    Ksenia Blinova, PhD (US Food and Drug Administration)
    Godfrey Smith, PhD (University of Glasgow)

    HESI Staff:
    Jennifer Pierson, MPH

  • Pro-Arrhythmia Working Group

    This working group is dedicated to investigating mechanisms of proarrhythmic risk. They continue to collaborate with the CiPA Initiative and ICH, and recently published its anticipated high throughput systems (HTS) ion channel work. A new subteam is scoping a conduction/ sodium channel paper to discuss the history and challenges surrounding this topic.

    A 3-phased project was conducted by the HESI Pro-Arrhythmia Working Group starting with a detailed literature review and followed by a collaborative HESI-FDA database of 150 new drug candidates to evaluate how predictive nonclinical studies are to clinical outcomes.

    • Related Publication: The Challenges of Predicting Drug-Induced QTc Prolongation in Humans. Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary Gintant, James Willard, Christine Garnett, Matthew Skinner, Hugo M Vargas, Todd Wisialowski, Michael K Pugsley. Toxicological Sciences. 11 February 2022

     

    Leadership Team:
    Jose Vicente Ruize, PhD (US Food and Drug Administration)
    Jean-Pierre Valentin, PhD (UCB Biopharma)

    HESI Staff:
    Jennifer Pierson, MPH

  • Integrative Strategies Working Group

    This working group has examined the sensitivity within a preclinical species to assess the function of contractility. They continue their partnership with University of Surrey and Imperial College London on a mathematical model to predict blood pressure changes. The Implanted Telemetry Subteam explored the impact of telemetry lead placement in toxicology studies (a collaboration with the Pro-Arrhythmia Working Group).

    Leadership Team:
    Michael Pugsley, PhD (Cytokinetics)
    Sandy Eldridge, PhD (National Cancer Institute)

    HESI Staff:
    E’Lissa Flores, PhD

  • Cardiac Biomarkers Working Group

    This working group is dedicated to investigating preclinical cardiac biomarkers of hypercoagulability induced under a thrombotic state, in both normal and diseased states. A manuscript was submitted detailing a study investigating the effects of doxorubicin in Zucker diabetic fatty rats. A new study is in the planning stages using xenobiotics to induce the procoagulant state and confirm measurements of biomarkers of interest.

    Leadership Team:
    Eric Schultze, PhD (Eli Lilly & Company)
    Marjory Brooks, DVM (Cornell University)

    HESI Staff:
    E’Lissa Flores, PhD

  • Cardiac Compound Tool (CCT) Database Subteam

    The Cardiac Safety Steering Team established this new subteam in early 2020 to develop and provide a structured resource for use when identifying compounds appropriate in a planned committee study. Delivery of this publicly accessible database is anticipated by the end of 2022.

    HESI Staff:
    Jennifer Pierson, MPH

  • COVID-19 Subteam

    This subteam was organized in May 2020 in response to the ongoing pandemic. Subteam members identified that emerging treatments for the novel coronavirus may have cardiotoxicities. The group is exploring how to gather cardiac safety data on five emerging therapies, whether prospective or retrospective, and develop a publication.

    HESI Staff:
    Jennifer Pierson, MPH

HESI Staff

Leadership Team

  • Brian Berridge, DVM, PhD

    National Institute of Environmental Health Sciences, National Toxicology Program

  • Norman Stockbridge, MD, PhD

    US Food and Drug Administration

Committee Events

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HESI Cardiac Safety Early Career Webinar Series – Shagun Krishna

May 12, 2022

HESI Cardiac Safety Early Career Webinar Series, Virtual

The HESI Cardiac Safety Committee is pleased to announce the final webinar in their Early Career Seminar Award Series. This competitive award is given to postdoctoral or early career scientists who have compelling research related to cardiovascular safety and risk assessment, and the webinar series offers an opportunity for ...

Read more

HESI Cardiac Safety Early Career Webinar Series – Arvin Soepriatna, Brown University

April 8, 2022

HESI Cardiac Safety Early Career Webinar Series, Virtual

The HESI Cardiac Safety Committee is pleased to announce the second webinar in their Early Career Seminar Award Series. This competitive award is given to postdoctoral or early career scientists who have compelling research related to cardiovascular safety and risk assessment, and the webinar series offers an opportunity for ...

Read more

HESI Cardiac Safety Committee Annual Meeting

February 28, 2022 – March 1, 2022

Virtual, Internal Committee Meeting

The HESI Cardiac Safety Committee will convene their annual business meeting on 28 February and 1 March 2022. The mission of the HESI Cardiac Safety Committee is to improve public health by reducing unanticipated cardiovascular-related adverse effects from drugs or chemicals, and to develop innovative ...

Read more

HESI Cardiac Safety Early Career Webinar Series

February 11, 2022

HESI Cardiac Safety Early Career Webinar Series, Virtual

The Cardiac Safety Steering Team is proud to present the first webinar series featuring Early Career Seminar Series Awardees. Dr. Julia Hotek,  Associate Principal Scientist at Merck, will present: Understanding hemodynamic changes: Use of signal processing tools to advance preclinical blood pressure analysis.

Read more

FDA Cardiac Safety Workshop

March 29, 2019

Silver Spring, Maryland, USA

FDA Workshop on Leveraging Human-Relevant Cardiomyocytes in Nonclinical Studies to Provide Mechanistic Insights into Cardiovascular Safety Liabilities

Read more

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Committee Publications

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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

International Journal of Toxicology, 2018

Emmanuel Boulay, Matthew M. Abernathy, Ray Chu, ...

Results from this limited retrospective electrocardiogram analysis suggest that JTpca and Tpeca may discriminate selective IKr blockers and multichannel blockers and could be considered in the context of an integrated comprehensive proarrhythmic risk assessment.

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An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

Journal of Pharmacological and Toxicological Methods, 2017

Michael K. Pugsley, Brian Guth, AlanY. Chiang, ...

The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety testing for years, the non-clinical assessment of drug effects on myocardial contractility is used less frequently with ...

Read more

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