Frontiers in Pharmacology, 2019
Ribeiro A, Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, ...
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provide mechanistic insight that can support the prediction of clinical cardiac drug ...
Frontiers in Pharmacology, 2019
Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, Gintant G, ...
- HESI - Health and Environmental Sciences Institute
Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclinical drug development. Detection of such effects earlier in drug research using ...
Toxicological Sciences, 2019
Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, ...
- HESI - Health and Environmental Sciences Institute
A consortium, multi-site approach to testing in vitro assay technology for prediction of drug-induced TdP. The authors sought to test calcium transient assays using the CiPA 28 drugs.
International Journal of Toxicology, 2018
Emmanuel Boulay, Matthew M. Abernathy, Ray Chu, ...
- HESI - Health and Environmental Sciences Institute
Results from this limited retrospective electrocardiogram analysis suggest that JTpca and Tpeca may discriminate selective IKr blockers and multichannel blockers and could be considered in the context of an integrated comprehensive proarrhythmic risk assessment.
Cell Reports, 2018
Blinova K., Dang Q., Millard D., Smith G., Pierson J., Liang G., ...
- HESI - Health and Environmental Sciences Institute
The HESI Cardiac Safety Myocyte Subteam completed a validation study with the CiPA 28, two commercial human cardiomyocyte cell lines, 5 devices across 10 sites. The results are published here.
Toxicological Sciences, 2018
Millard D, Dang Q, Shi H, Zhang X, Strock C, Kraushaar U, Zeng H, ...
- HESI - Health and Environmental Sciences Institute
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