Toxicologic Pathology, 2010
Clements P, Brady S, York M, Berridge B, Mikaelian I, Nicklaus R, ...
We investigated the kinetics of circulating biomarker elevation, specifically correlated with morphology in acute myocardial injury.
Journal of Pharmacological and Toxicological Methods, 2010
Pettit SD, Berridge B, Sarazan RD
Cardiovascular safety concerns are a significant cause of attrition in the development of new drugs (Lasser et al., 2002).
International Journal of Toxicology, 2011
Sarazan RD, Mittelstadt S, Guth B, Koerner J, Zhang J, Pettit S
There are several recent examples where clinically significant, safety-related, drug effects on hemodynamics or cardiac function were not apparent until large clinical trials were completed or the drugs entered the consumer market.
Journal of Pharmacological and Toxicological Methods, 2013
Pierson JB, Berridge BR, Brooks MB, Dreher K, Koerner J, ...
The evaluation of cardiovascular side-effects is a critical element in the development of all new drugs and chemicals.
Regulatory Toxicology and Pharmacology, 2013
Berridge BR, Hoffmann P, Turk JR, Sellke F, Gintant G, Hirkaler G, ...
Cardiovascular (CV) safety concerns are a significant source of drug development attrition in the pharmaceutical industry today.
Toxicologic Pathology, 2013
Reagan WJ, York M, Berridge B, Schultze E, Walker D, Pettit S
Cardiac troponin (cTn) has been utilized to assess acute myocardial injury, but the cTn response in active/ongoing chronic injury is not well documented.
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