Cardiac Safety Committee

Mission Statement

The mission of the HESI Cardiac Safety Committee is to improve public health by reducing unanticipated cardiovascular-related adverse effects from drugs or chemicals, and to develop innovative approaches to support early detection and prediction as well as improved understanding of cardiovascular toxicology and pathobiology.

Cardiac Safety Committee Early Career Seminar Award Series

The HESI Cardiac Safety Committee is excited to announce the winners for the committee’s new Early Career Seminar Award Series. This award offers an opportunity for postdocs and early career scientists to share their research, learn from, and network with experts in the toxicology and safety pharmacology fields from academia, regulatory agencies, and pharmaceutical companies. Awardees receive a $500 USD award and are invited to present their research on a public webinar with Cardiac Safety Committee members and other invited guests.

Three awardees were selected for this inaugural Seminar Series:

  • Dr. Julia Hotek, Merck (see event details)
  • Dr. Arvin Soepriatna, Brown University
  • Dr. Shagun Krishna, NTP-NIEHS

Working Groups

  • Stem Cell Working Group

    This group is working to understand and characterize use of stem cell–derived cardiomyocytes in cardiac safety assessments. An article that included best practices for use of stem cell cardiomyocytes in cardiac safety assessments was published in Regulatory Toxicology and Pharmacology. A new group is planning a study to explore in vitro assay ability to detect cardiotoxicity.

    Leadership Team:
    Ksenia Blinova, PhD (US Food and Drug Administration)
    Godfrey Smith, PhD (University of Glasgow)

    HESI Staff:
    Jennifer Pierson, MPH

  • Pro-Arrhythmia Working Group

    This working group is dedicated to investigating mechanisms of proarrhythmic risk. They continue to collaborate with the CiPA Initiative and ICH, and recently published its anticipated high throughput systems (HTS) ion channel work. A new subteam is scoping a conduction/ sodium channel paper to discuss the history and challenges surrounding this topic.

    A 3-phased project was conducted by the HESI Pro-Arrhythmia Working Group starting with a detailed literature review and followed by a collaborative HESI-FDA database of 150 new drug candidates to evaluate how predictive nonclinical studies are to clinical outcomes.

    • Related Publication: The Challenges of Predicting Drug-Induced QTc Prolongation in Humans. Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary Gintant, James Willard, Christine Garnett, Matthew Skinner, Hugo M Vargas, Todd Wisialowski, Michael K Pugsley. Toxicological Sciences. 11 February 2022

     

    Leadership Team:
    Jose Vicente Ruize, PhD (US Food and Drug Administration)
    Jean-Pierre Valentin, PhD (UCB Biopharma)

    HESI Staff:
    Jennifer Pierson, MPH

  • Integrative Strategies Working Group

    This working group has examined the sensitivity within a preclinical species to assess the function of contractility. They continue their partnership with University of Surrey and Imperial College London on a mathematical model to predict blood pressure changes. The Implanted Telemetry Subteam explored the impact of telemetry lead placement in toxicology studies (a collaboration with the Pro-Arrhythmia Working Group).

    Leadership Team:
    Michael Pugsley, PhD (Cytokinetics)
    Sandy Eldridge, PhD (National Cancer Institute)

    HESI Staff:
    E’Lissa Flores, PhD

  • Cardiac Biomarkers Working Group

    This working group is dedicated to investigating preclinical cardiac biomarkers of hypercoagulability induced under a thrombotic state, in both normal and diseased states. A manuscript was submitted detailing a study investigating the effects of doxorubicin in Zucker diabetic fatty rats. A new study is in the planning stages using xenobiotics to induce the procoagulant state and confirm measurements of biomarkers of interest.

    Leadership Team:
    Eric Schultze, PhD (Eli Lilly & Company)
    Marjory Brooks, DVM (Cornell University)

    HESI Staff:
    E’Lissa Flores, PhD

  • Cardiac Compound Tool (CCT) Database Subteam

    The Cardiac Safety Steering Team established this new subteam in early 2020 to develop and provide a structured resource for use when identifying compounds appropriate in a planned committee study. Delivery of this publicly accessible database is anticipated by the end of 2022.

    HESI Staff:
    Jennifer Pierson, MPH

  • COVID-19 Subteam

    This subteam was organized in May 2020 in response to the ongoing pandemic. Subteam members identified that emerging treatments for the novel coronavirus may have cardiotoxicities. The group is exploring how to gather cardiac safety data on five emerging therapies, whether prospective or retrospective, and develop a publication.

    HESI Staff:
    Jennifer Pierson, MPH

HESI Staff

Leadership Team

  • Brian Berridge, DVM, PhD

    National Institute of Environmental Health Sciences, National Toxicology Program

  • Norman Stockbridge, MD, PhD

    US Food and Drug Administration

Committee Events

Filter

HESI Cardiac Safety Early Career Webinar Series – Shagun Krishna

May 12, 2022

HESI Cardiac Safety Early Career Webinar Series, Virtual

The HESI Cardiac Safety Committee is pleased to announce the final webinar in their Early Career Seminar Award Series. This competitive award is given to postdoctoral or early career scientists who have compelling research related to cardiovascular safety and risk assessment, and the webinar series offers an opportunity for ...

Read more

HESI Cardiac Safety Early Career Webinar Series – Arvin Soepriatna, Brown University

April 8, 2022

HESI Cardiac Safety Early Career Webinar Series, Virtual

The HESI Cardiac Safety Committee is pleased to announce the second webinar in their Early Career Seminar Award Series. This competitive award is given to postdoctoral or early career scientists who have compelling research related to cardiovascular safety and risk assessment, and the webinar series offers an opportunity for ...

Read more

HESI Cardiac Safety Committee Annual Meeting

February 28, 2022 – March 1, 2022

Virtual, Internal Committee Meeting

The HESI Cardiac Safety Committee will convene their annual business meeting on 28 February and 1 March 2022. The mission of the HESI Cardiac Safety Committee is to improve public health by reducing unanticipated cardiovascular-related adverse effects from drugs or chemicals, and to develop innovative ...

Read more

HESI Cardiac Safety Early Career Webinar Series

February 11, 2022

HESI Cardiac Safety Early Career Webinar Series, Virtual

The Cardiac Safety Steering Team is proud to present the first webinar series featuring Early Career Seminar Series Awardees. Dr. Julia Hotek,  Associate Principal Scientist at Merck, will present: Understanding hemodynamic changes: Use of signal processing tools to advance preclinical blood pressure analysis.

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => event
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [before] => 2050-01-01
            [after] => 
            [tags] => Cardiac Safety
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => Array
                        (
                            [0] => AND
                            [1] => AND
                        )

                    [0] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2050-01-01
                            [compare] => <=
                        )

                    [1] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2050-01-01
                            [compare] => <=
                        )

                    [2] => Array
                        (
                            [key] => _ilsi_date
                            [value] => Array
                                (
                                    [0] => 2022-01-01
                                    [1] => 2022-05-19
                                )

                            [compare] => BETWEEN
                        )

                    [3] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2022-05-19
                            [compare] => <
                        )

                )

            [paged] => 1
            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [field] => name
                            [terms] => Cardiac Safety
                        )

                )

            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => event
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [before] => 2050-01-01
            [after] => 
            [tags] => Cardiac Safety
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => Array
                        (
                            [0] => AND
                            [1] => AND
                        )

                    [0] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2050-01-01
                            [compare] => <=
                        )

                    [1] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2050-01-01
                            [compare] => <=
                        )

                    [2] => Array
                        (
                            [key] => _ilsi_date
                            [value] => Array
                                (
                                    [0] => 2022-01-01
                                    [1] => 2022-05-19
                                )

                            [compare] => BETWEEN
                        )

                    [3] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2022-05-19
                            [compare] => <
                        )

                )

            [paged] => 1
            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [field] => name
                            [terms] => Cardiac Safety
                        )

                )

            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 200
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [suppress_filters] => 
            [ignore_sticky_posts] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [terms] => Array
                                (
                                    [0] => Cardiac Safety
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_term_relationships
                )

            [queried_terms] => Array
                (
                    [post_tag] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Cardiac Safety
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [1] => Array
                        (
                            [0] => Array
                                (
                                    [key] => _ilsi_date
                                    [value] => 2050-01-01
                                    [compare] => <=
                                )

                            [1] => Array
                                (
                                    [key] => _ilsi_end_date
                                    [value] => 2050-01-01
                                    [compare] => <=
                                )

                            [2] => Array
                                (
                                    [key] => _ilsi_date
                                    [value] => Array
                                        (
                                            [0] => 2022-01-01
                                            [1] => 2022-05-19
                                        )

                                    [compare] => BETWEEN
                                )

                            [3] => Array
                                (
                                    [key] => _ilsi_date
                                    [value] => 2022-05-19
                                    [compare] => <
                                )

                            [relation] => AND
                        )

                    [relation] => AND
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                    [1] => mt1
                    [2] => mt2
                    [3] => mt3
                    [4] => mt4
                )

            [clauses:protected] => Array
                (
                    [wp_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
                        )

                    [mt1] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2050-01-01
                            [compare] => <=
                            [compare_key] => =
                            [alias] => mt1
                            [cast] => CHAR
                        )

                    [mt2] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2050-01-01
                            [compare] => <=
                            [compare_key] => =
                            [alias] => mt2
                            [cast] => CHAR
                        )

                    [mt3] => Array
                        (
                            [key] => _ilsi_date
                            [value] => Array
                                (
                                    [0] => 2022-01-01
                                    [1] => 2022-05-19
                                )

                            [compare] => BETWEEN
                            [compare_key] => =
                            [alias] => mt3
                            [cast] => CHAR
                        )

                    [mt4] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2022-05-19
                            [compare] => <
                            [compare_key] => =
                            [alias] => mt4
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID FROM wp_posts  LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id) INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )  INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )  INNER JOIN wp_postmeta AS mt2 ON ( wp_posts.ID = mt2.post_id )  INNER JOIN wp_postmeta AS mt3 ON ( wp_posts.ID = mt3.post_id )  INNER JOIN wp_postmeta AS mt4 ON ( wp_posts.ID = mt4.post_id ) WHERE 1=1  AND ( 
  wp_term_relationships.term_taxonomy_id IN (200)
) AND ( 
  wp_postmeta.meta_key = '_ilsi_date' 
  AND 
  ( 
    ( mt1.meta_key = '_ilsi_date' AND mt1.meta_value <= '2050-01-01' ) 
    AND 
    ( mt2.meta_key = '_ilsi_end_date' AND mt2.meta_value <= '2050-01-01' ) 
    AND 
    ( mt3.meta_key = '_ilsi_date' AND mt3.meta_value BETWEEN '2022-01-01' AND '2022-05-19' ) 
    AND 
    ( mt4.meta_key = '_ilsi_date' AND mt4.meta_value < '2022-05-19' )
  )
) AND ((wp_posts.post_type = 'event' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled'))) GROUP BY wp_posts.ID ORDER BY wp_postmeta.meta_value DESC LIMIT 0, 6
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 24994
                    [post_author] => 16
                    [post_date] => 2022-04-14 12:57:30
                    [post_date_gmt] => 2022-04-14 12:57:30
                    [post_content] => 
                    [post_title] => HESI Cardiac Safety Early Career Webinar Series - Shagun Krishna
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => hesi-cardiac-safety-early-career-webinar-series-krishna
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-04-15 13:14:37
                    [post_modified_gmt] => 2022-04-15 13:14:37
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/event/hesi-cardiac-safety-early-career-webinar-series-soepriatna-copy/
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 24739
                    [post_author] => 16
                    [post_date] => 2022-03-11 13:37:06
                    [post_date_gmt] => 2022-03-11 13:37:06
                    [post_content] => 
                    [post_title] => HESI Cardiac Safety Early Career Webinar Series - Arvin Soepriatna, Brown University
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => hesi-cardiac-safety-early-career-webinar-series-soepriatna
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-03-11 13:47:05
                    [post_modified_gmt] => 2022-03-11 13:47:05
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/event/hesi-cardiac-safety-early-career-webinar-series-copy/
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 24525
                    [post_author] => 16
                    [post_date] => 2022-02-03 20:09:56
                    [post_date_gmt] => 2022-02-03 20:09:56
                    [post_content] => 
                    [post_title] => HESI Cardiac Safety Committee Annual Meeting
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => hesi-cardiac-safety-committee-annual-meeting
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-02-03 20:09:56
                    [post_modified_gmt] => 2022-02-03 20:09:56
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=event&p=24525
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 24454
                    [post_author] => 16
                    [post_date] => 2022-01-20 14:21:40
                    [post_date_gmt] => 2022-01-20 14:21:40
                    [post_content] => 
                    [post_title] => HESI Cardiac Safety Early Career Webinar Series
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => hesi-cardiac-safety-early-career-webinar-series
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-01-20 14:46:16
                    [post_modified_gmt] => 2022-01-20 14:46:16
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=event&p=24454
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 4
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 24994
            [post_author] => 16
            [post_date] => 2022-04-14 12:57:30
            [post_date_gmt] => 2022-04-14 12:57:30
            [post_content] => 
            [post_title] => HESI Cardiac Safety Early Career Webinar Series - Shagun Krishna
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => hesi-cardiac-safety-early-career-webinar-series-krishna
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2022-04-15 13:14:37
            [post_modified_gmt] => 2022-04-15 13:14:37
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/event/hesi-cardiac-safety-early-career-webinar-series-soepriatna-copy/
            [menu_order] => 0
            [post_type] => event
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 4
    [max_num_pages] => 1
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 1
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 915662e704fc58803844a2e3bb44c023
    [query_vars_changed:WP_Query:private] => 1
    [thumbnails_cached] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Committee Publications

Filter

Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy

Journal of Pharmacological and Toxicological Methods, 2021

Pugsley MK, Brooks MB, Fishman CE, Katavolos P, Chiang AY, ...

Zucker diabetic fatty (ZDF) rats are used widely as an animal model of metabolic syndrome and insulin resistance. Our study focused on the effects of high versus low dietary fat on the development of Type 2 diabetes in obese male ZDF rats (fa/fa), including biomarkers to detect early signs of hypercoagulability and vascular injury ...

Read more

The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.

J Pharmacol Toxicol Methods., 2018

Chiang AY, Guth BD, Pugsley MK, Foley CM, Doyle JM, Engwall MJ, ...

The HESI Cardiac Safety Committee designed and conducted studies to evaluate inherent variability in telemetry implanted dogs. This paper discusses details of the statistical methods used to evaluate a primary endpoint for measuring blood pressure changes.

Read more

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress

Journal of Pharmacological and Toxicological Methods, 2016

Colatsky T, Fermini B, Gintant G, Pierson J, Sager P, Sekino Y, ...

The implementation of the ICH S7B and E14 guidelines has been successful in preventing the introduction of potentially torsadogenic drugs to the market, but it has also unduly constrained drug development by focusing on hERG block and QT prolongation as essential determinants of proarrhythmia risk.

Read more

The Challenges of Predicting Drug-Induced QTc Prolongation in Humans

Toxicological Sciences, 2022

Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, ...

New publication in Toxicological Sciences by the HESI Cardiac Safety Committee shows that nonclinical models used to predict cardiac safety during drug development do not absolutely replicate the clinical conditions; however, best practices can be used to improve the nonclinical assay quality and achieve the ...

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => Cardiac Safety
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Cardiac Safety
                        )

                )

            [paged] => 1
            [orderby] => title
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => Cardiac Safety
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Cardiac Safety
                        )

                )

            [paged] => 1
            [orderby] => title
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_key] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [suppress_filters] => 
            [ignore_sticky_posts] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [taxonomy] => ilsi_committee
            [term_id] => Cardiac Safety
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [terms] => Array
                                (
                                    [0] => Cardiac Safety
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_term_relationships
                )

            [queried_terms] => Array
                (
                    [ilsi_committee] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Cardiac Safety
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [meta_table] => 
            [meta_id_column] => 
            [primary_table] => 
            [primary_id_column] => 
            [table_aliases:protected] => Array
                (
                )

            [clauses:protected] => Array
                (
                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID FROM wp_posts  LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id) WHERE 1=1  AND ( 
  wp_term_relationships.term_taxonomy_id IN (17)
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled'))) GROUP BY wp_posts.ID ORDER BY wp_posts.post_title DESC LIMIT 0, 6
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 23746
                    [post_author] => 2
                    [post_date] => 2020-11-10 18:31:59
                    [post_date_gmt] => 2020-11-10 18:31:59
                    [post_content] => 
                    [post_title] => Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => use-of-the-zdf-rat-to-model-dietary-fat-induced-hypercoagulability-is-limited-by-progressive-and-fatal-nephropathy
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2021-10-25 13:53:36
                    [post_modified_gmt] => 2021-10-25 13:53:36
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=23746
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 3250
                    [post_author] => 6
                    [post_date] => 2016-06-20 11:49:06
                    [post_date_gmt] => 2016-06-20 16:49:06
                    [post_content] => 
                    [post_title] => Time Course Characterization of Serum Cardiac Troponins, Heart Fatty Acid–Binding Protein, and Morphologic Findings With Isoproterenol-Induced Myocardial Injury in the Rat
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => time-course-characterization-of-serum-cardiac-troponins-heart-fatty-acid-binding-protein-and-morphologic-findings-with-isoproterenol-induced-myocardial-injury-in-the-rat
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-20 11:49:06
                    [post_modified_gmt] => 2016-06-20 16:49:06
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3250
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 21093
                    [post_author] => 8
                    [post_date] => 2019-04-09 09:21:38
                    [post_date_gmt] => 2019-04-09 14:21:38
                    [post_content] => 
                    [post_title] => The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-evaluation-of-endpoint-variability-and-implications-for-study-statistical-power-and-sample-size-in-conscious-instrumented-dogs
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2019-04-09 09:21:38
                    [post_modified_gmt] => 2019-04-09 14:21:38
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=21093
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 1965
                    [post_author] => 6
                    [post_date] => 2016-04-17 21:43:53
                    [post_date_gmt] => 2016-04-18 02:43:53
                    [post_content] => 
                    [post_title] => The Evaluation of Drug-Induced Changes in Cardiac Inotropy in Dogs: Results From a HESI-Sponsored Consortium
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-evaluation-of-drug-induced-changes-in-cardiac-inotropy-in-dogs-results-from-a-hesi-sponsored-consortium
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-04-17 21:43:53
                    [post_modified_gmt] => 2016-04-18 02:43:53
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=1965
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 3284
                    [post_author] => 7
                    [post_date] => 2016-06-21 10:30:57
                    [post_date_gmt] => 2016-06-21 15:30:57
                    [post_content] => 
                    [post_title] => The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative — Update on progress
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-comprehensive-in-vitro-proarrhythmia-assay-cipa-initiative-update-on-progress
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-21 10:30:57
                    [post_modified_gmt] => 2016-06-21 15:30:57
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3284
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 24853
                    [post_author] => 16
                    [post_date] => 2022-04-01 12:01:31
                    [post_date_gmt] => 2022-04-01 12:01:31
                    [post_content] => 
                    [post_title] => The Challenges of Predicting Drug-Induced QTc Prolongation in Humans
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-challenges-of-predicting-drug-induced-qtc-prolongation-in-humans
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-04-01 12:34:11
                    [post_modified_gmt] => 2022-04-01 12:34:11
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=24853
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 23746
            [post_author] => 2
            [post_date] => 2020-11-10 18:31:59
            [post_date_gmt] => 2020-11-10 18:31:59
            [post_content] => 
            [post_title] => Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => use-of-the-zdf-rat-to-model-dietary-fat-induced-hypercoagulability-is-limited-by-progressive-and-fatal-nephropathy
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2021-10-25 13:53:36
            [post_modified_gmt] => 2021-10-25 13:53:36
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=23746
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 36
    [max_num_pages] => 6
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 1
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 108a38480015eacbb03a06107e866a3a
    [query_vars_changed:WP_Query:private] => 1
    [thumbnails_cached] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.