This protocol is provided for testing of nanomaterials (NM) with standard cell lines in the absence of metabolic activation.
In Vitro Micronucleus Assay: method for assessment of nanomaterials using Cytochalasin B.
Frontiers in Toxicology, 2023
Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.
Frontiers in Toxicology, 2023
This protocol is provided for testing of nanomaterials (NM) with standard cell lines in the absence of metabolic activation.
Journal of Pharmacological and Toxicological Methods, 2023
Members of the HESI Cardiac Safety Committee pooled retrospective data to explore the incidence of spontaneous arrhythmias and effect of telemetry implants in species typically used in safety pharmacology studies.
JoVE Journal, 2023
Editorial published in JoVE by the HESI Cardiac Safety Committee
Regenerative Medicine, 2023
HESI’s Cell Therapy-TRAcking, Circulation & Safety Technical Committee completed an international, multisite study to evaluate the sensitivity and reproducibility of the highly efficient culture (HEC) assay, an in vitro assay to detect residual undifferentiated human pluripotent stem cells (hPSCs) in cell therapy ...
Environmental Toxicology and Chemistry, 2023
A new critical review by Mitchell et al., published in Environmental Toxicology and Chemistry, examines the potential for expanding the use of New Approach Methodologies (NAMs) in endocrine activity testing and assessment.
Journal of Immunotoxicology, 2023
An insightful review by Kamperschoer et al. that provides an overview of the various methods for assessment of Cytotoxic T Lymphocytes (CTL) function in Non-Human Primates in the context of non-clinical safety assessment of immune-modulating therapeutic agents.
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