Impact of HESI Publications

Respected Science

HESI’s scientific programs provide an opportunity for academic, government, and industry scientists to interact on a peer-to-peer basis to address both emerging and long-standing challenges in safety evaluation. The ongoing researches, discussions, critiques, and sharing of best practices within HESI are valuable contributions to the practice of science as evidence by the examples below.

Global Impact through Peer-Reviewed Science 

Almost 300 publications from HESI scientific programs over the last 25 years - more than 100+ publications in the peer reviewed literature in the last decade.


HESI publications have been cited 4,625 times in more than 1000 different scientific journals by scientists from 1300 organizations (academic, government, industry, foundations, hospitals, etc.) in 71 different countries.

Multidisciplinary Relevance and Scope

This figure shows the number of times HESI publications were cited in each calendar year and the focus of the journal in which they were cited.

HESI papers routinely win awards for their impact and relevance.  A few examples:

Awarded: Environmental and Molecular Mutagenesis Editor’s Choice and Best Papers published in 2014 Advancing the Science of Risk Assessment by the Society of Toxicology’s Risk Assessment Specialty Section.



Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Mol Mutagen, 2014, 55(8):609-23. Johnson GE, Soeteman-Hernández LG, Gollapudi BB, Bodger OG, Dearfield KL, Heflich RH, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. Available open access.


Awarded: SOT Risk Assessment Specialty Section Top 10 Paper for Advancing the Science of Risk Assessment 2012.

  Quantitative approaches for assessing dose-response relationships in genetic toxicology studies. Environmental and Molecular Mutagenesis (2013) Volume 54, Number 1, pp 8-18 B.B. Gollapudi, G.E. Johnson, L.G.Hernandez, L.H. Pottenger, K.L. Dearfield, A.M. Jeffrey, E. Julien, J.H. Kim, D.P. Lovell, J.T. MacGregor, M.M. Moore, J. van Benthem, P.A.White, E. Zeiger, and V.Thybaud
  This paper, developed by the HESI Genetic Toxicology Technical Committee, revolutionizes the analysis of genotoxicity data by applying quantitative approaches. Genotoxicity has previously been assessed qualitatively, with a dichotomous “positive” or “negative” result, thus limiting risk decisionmaking.

Awarded: SETAC Best Paper Award 2012, Honorable Mention and SOT Risk Assessment Specialty Section Top 10 Paper for Advancing the Science of Risk Assessment 2012.



Explaining differences between bioaccumulation measurements in laboratory and fi eld data through use of a probabilistic modeling approach. Integrated Environmental Assessment and Management (2012) Volume 8, Number 1, pp 42 -63 H. Selck, K. Drouillard, K. Eisenreich, A.A. Koelmans, A. Palmqvist, A. Ruus, D.Salvito, I.Schultz, R. Stewart, A. Weisbrod, N.W. van den Brink, and M. van den Heuvel-Greve

This paper, developed by the HESI Development of Methods for a Tiered Approach to Assess the Bioaccumulation of Chemicals Project Committee, makes a unique contribution to the field by reporting on a quantitative study of the combined influence of physicochemical, physiological, ecological, and environmental parameters known to affect bioaccumulation and whether uncertainty in these factors can explain the observed differences among laboratory and field studies.