Impact of HESI Publications

Respected Science

HESI’s scientific programs provide an opportunity for academic, government, and industry scientists to interact on a peer-to-peer basis to address both emerging and long-standing challenges in safety evaluation. The ongoing researches, discussions, critiques, and sharing of best practices within HESI are valuable contributions to the practice of science as evidence by the examples below.

Global Impact through Peer-Reviewed Science 

Over 335 publications from HESI scientific programs have been published throughout the last 30 years, with more than 100 publications in peer-reviewed literature in the last decade.
HESI publications have been cited nearly 20,000 times in more than 3,600 different scientific journals by scientists from over 1,600 organizations (academic, government, industry, foundations, hospitals, etc.) in 75 different countries.

Citations for HESI Publications by Year

This figure shows the number of times HESI publications were cited in each calendar year. Citations of HESI publications have consistently increased each year, with 2018 looking to surpass 2017.

Citation Activity by Publication and Year

Citations for individual HESI publications (each publication is represented by a different color) by year shows a clear upward trend.

Geographic Distribution of Lead Citing Authors

This figure uses colors for each country to show the wide geographic coverage of organizational affiliations for lead citing authors.

Types of Organizational Affiliations for Lead Citing Authors

The primary authors of articles citing HESI publications represent 1,653 different organizations including a wide variety of government, institute/nonprofit, academic, and commercial entities.

HESI papers routinely win awards for their impact and relevance.  A few examples:

Awarded: DIA Author of the Year 2017 and most downloaded publication of 2017.

Birth Control in Clinical Trials: Industry Survey of Current Use Practices, Governance, and Monitoring (2016). Therapeutic Innovation & Regulatory Science, Stewart J, Breslin WJ, Beyer BK, Chadwick K, De Schaepdrijver L, Desai M, Enright B, Foster W, Hui JY, Moffat GJ, Tornesi B, Van Malderen K, Wiesner L, Chen CL. Available online here.

Awarded: Environmental and Molecular Mutagenesis Editor’s Choice and Best Papers published in 2014 Advancing the Science of Risk Assessment by the Society of Toxicology’s Risk Assessment Specialty Section.

Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ Mol Mutagen, 2014, 55(8):609-23. Johnson GE, Soeteman-Hernández LG, Gollapudi BB, Bodger OG, Dearfield KL, Heflich RH, Hixon JG, Lovell DP, MacGregor JT, Pottenger LH, Thompson CM, Abraham L, Thybaud V, Tanir JY, Zeiger E, van Benthem J, White PA. Available online here.

 

Awarded: SOT Risk Assessment Specialty Section Top 10 Paper for Advancing the Science of Risk Assessment 2012.

Quantitative approaches for assessing dose-response relationships in genetic toxicology studies. Environmental and Molecular Mutagenesis (2013) Volume 54, Number 1, pp 8-18 B.B. Gollapudi, G.E. Johnson, L.G.Hernandez, L.H. Pottenger, K.L. Dearfield, A.M. Jeffrey, E. Julien, J.H. Kim, D.P. Lovell, J.T. MacGregor, M.M. Moore, J. van Benthem, P.A.White, E. Zeiger, and V. Thybaud
This paper, developed by the HESI Genetic Toxicology Technical Committee, revolutionizes the analysis of genotoxicity data by applying quantitative approaches. Genotoxicity has previously been assessed qualitatively, with a dichotomous “positive” or “negative” result, thus limiting risk decision-making.

Awarded: SETAC Best Paper Award 2012, Honorable Mention and SOT Risk Assessment Specialty Section Top 10 Paper for Advancing the Science of Risk Assessment 2012.

Explaining differences between bioaccumulation measurements in laboratory and fi eld data through use of a probabilistic modeling approach. Integrated Environmental Assessment and Management (2012) Volume 8, Number 1, pp 42 -63 H. Selck, K. Drouillard, K. Eisenreich, A.A. Koelmans, A. Palmqvist, A. Ruus, D.Salvito, I.Schultz, R. Stewart, A. Weisbrod, N.W. van den Brink, and M. van den Heuvel-Greve
This paper, developed by the HESI Development of Methods for a Tiered Approach to Assess the Bioaccumulation of Chemicals Project Committee, makes a unique contribution to the field by reporting on a quantitative study of the combined influence of physicochemical, physiological, ecological, and environmental parameters known to affect bioaccumulation and whether uncertainty in these factors can explain the observed differences among laboratory and field studies.