The Gut Microbiome Workshop

The Gut Microbiome: Markers of Human Health, Drug Efficacy and Xenobiotic Toxicity
Alexandria, VA, United States
June 25, 2018 – June 26, 2018

medium dreamstime image

The Gut Microbiome: Markers of Human Health,

Drug Efficacy and Xenobiotic Toxicity

 

June 25 - 26

Holiday Inn & Suites Alexandria - Old Town
625 First Street
Alexandria, Virginia

The gut microbiome is believed to play an important role in human health in areas as diverse as brain function and the immune system.  Exploring host-microbiome interactions will provide a mechanistic understanding and enable new insights in human diseases (i.e., their diagnosis, prognosis and treatment) and new perceptions of xenobiotic efficacy and/or toxicity. This workshop will review the science and initiate discussions on multiple topics, including a) identification of biomarkers of toxicity for alterations in gut microbial function, b) if changes in the microbiome can affect efficacy of medicines and c) if exposure to xenobiotics can eventually result in a disease state through changes in the microbiome.  Conclusions from his workshop will help determine where the data gaps are so that researchers can start answering these questions.

WORKSHOP GOAL
To identify data gaps that can be addressed to help determine if alterations in the gut microbiome have an effect on human health.

Microbiome

WORKSHOP AIMS
1.  To discuss and review the current science on the gut microbiome and identify areas of interest regarding its role in human health
2.  To discuss our understanding on how xenobiotic toxicity affects the microbiome
3.  To understand if there are biomarkers of disease or organ damage due to:
     -  Alterations of microbiome structure and function
     -  Endogenous microbial metabolites

Workshop Agenda [Download Agenda]

Plenary

 

Drugging Gut Microbial Enzymes for the Treatment of Cardiometabolic Disease
Mark Brown, Cleveland Clinic                                                                     

Session 1: Biotransformation

Overview of Biotransformation of Xenobiotics by Microbiota

Julia Cui, University of Washington [Download Presentation]

 

Gut Microbial Transformation – Endogenous and Exogenous Metabolites & Effect of Xenobiotics on Microbial Composition and Endogenous Functions

Gary Perdew, Penn State University

 

Modification of Chemical Effects by Microbiome?

Andrew Patterson, Penn State University

 

Session 2: Biomarkers of Adverse Effects

What is an Adverse Effect?

Rodney Dietert, Cornell University [Download Presentation]

 

Where to Look for Biomarkers?

Carrie Brodmerkel, Janssen [Download Presentation]

 

Challenges in Determining Sensitive Biomarkers of Dysbiosis When Assessing the Impact of Antimicrobial Drug Residues in Food on the Human Intestinal Microbiome

Carl Cerniglia, US FDA-NCTR [Download Presentation]

 

What are the Tools and Technologies Needed?

Joseph Petrosino, Baylor College of Medicine [Download Presentation]

 

Session 3: Biomarkers of Toxicity & Disease

Toxicity and Environmental Pollutants

Kun Lu, University of North Carolina Chapel Hill

 

Identification of Microbiome-based Biomarkers and Challenges Associated with their Application: Case Studies from Obesity, IBD, and Cancer

Emily Hollister, Diversigen [Download Presentation]

 

The Microbiome and Hypertension

Elaine Richards Sumners, University of Florida [Download Presentation]

 

Session 4: Human Susceptibility

Health Insights from Microbiomes in the Context of Personal, Dense, Dynamic, Data Clouds

Nathan Price, Institute for Systems Biology

 

Age – Early & Late Life

Eugene Chang, University of Chicago [Download Presentation]

 

Gender and the Gut Microbiome

Marijke Faas, University of Groningen

 

Session 5: Key Animal Models

Overview of Key Factors Known to Affect Composition of Laboratory Rodent Gut Microbiome

Aaron Ericsson, University of Missouri [Download Presentation]

 

Natural World Versus Laboratory World: Natural Gut Microbiota from Wild Mice Improve Host Fitness in Viral Infection and Carcinogenesis Models

Barbara Rehermann, NIH/NIDDK [Download Presentation]

 

Investigating Interactions Between Chemicals and Microbiota in Zebrafish

Tamara Tal, US EPA