Subcommittee on the Microbiome

Subcommittee on the Microbiome

Mission Statement

 

The mission of the HESI Microbiome Subcommittee is to examine gut microbial-host dynamics to understand how the gut microbiome affects human health, drug efficacy and xenobiotic toxicity. The focus is to identify markers contributing to or resulting from disease or organ damage, including:

  • alterations of the microbial community structure and microbiome function;
  • endogenous microbial metabolites; and/or
  • microbiota metabolism of exogenous compounds

 

View the proposal presented at the 2016 Annual Meeting here.

Committee Contacts

HESI Staff

Connie Chen, PhD, MPH
cchen@hesiglobal.org

Lauren Peel
lpeel@hesiglobal.org

Leadership Team

Donna Gulezian
Taconic Biosciences

Donna Mendrick, PhD
US FDA/National Center for Toxicology Research

Vicki Sutherland, PhD
NIEHS/National Toxicology Program

Members and Fact Sheet

Committee Events

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Upcoming Events

The Gut Microbiome Workshop

Alexandria, VA, United States

A 2-day workshop to address the state of the science and data gaps in gut microbiome research.

Read more

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				medium dreamstime image
	

 

The Gut Microbiome: Markers of Human Health,

Drug Efficacy and Xenobiotic Toxicity

The gut microbiome is believed to play an important role in human health in areas as diverse as brain function and the immune system.  Exploring host-microbiome interactions will provide a mechanistic understanding and enable new insights in human diseases (i.e., their diagnosis, prognosis and treatment) and new perceptions of xenobiotic efficacy and/or toxicity. This workshop will review the science and initiate discussions on multiple topics, including a) identification of biomarkers of toxicity for alterations in gut microbial function, b) if changes in the microbiome can affect efficacy of medicines and c) if exposure to xenobiotics can eventually result in a disease state through changes in the microbiome.  Conclusions from his workshop will help determine where the data gaps are so that researchers can start answering these questions.

WORKSHOP GOAL
To identify data gaps that can be addressed to help determine if alterations in the gut microbiome have an effect on human health.

guthealth

WORKSHOP AIMS
1.  To discuss and review the current science on the gut microbiome and identify areas of interest regarding its role in human health
2.  To discuss our understanding on how xenobiotic toxicity affects the microbiome
3.  To understand if there are biomarkers of disease or organ damage due to:
     -  Alterations of microbiome structure and function
     -  Endogenous microbial metabolites

CONFIRMED SPEAKERS 

Elena Biagi, University of Bologna                Kun Lu, University of North Carolina, Chapel Hill
Carrie Brodmerkel, Janssen                           Jeremy Nicholson, Imperial College London   
Mark Brown, Cleveland Clinic                        Andrew Patterson, Pennsylvania State University
Carl Cerniglia, US FDA, NCTR                        Gary Perdew, Pennsylvania State University
Eugene Chang, University of Chicago           Joseph Petrosino, Baylor College of Medicine
Julia Cui, University of Washington              Nathan Price, Institute for Systems Biology
Anna Mae Diehl, Duke University                  Mohan Raizada, University of Florida
Rodney Dietart, Cornell University                Barbara Reherhman, NIDDK
Aaron Erickson, University of Missouri
Marijke Faas, University of Groningen

To receive updates, please fill in the following information:
 
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REGISTRATION WILL OPEN IN EARLY 2018.

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The Gut Microbiome: Markers of Human Health,

Drug Efficacy and Xenobiotic Toxicity

The gut microbiome is believed to play an important role in human health in areas as diverse as brain function and the immune system.  Exploring host-microbiome interactions will provide a mechanistic understanding and enable new insights in human diseases (i.e., their diagnosis, prognosis and treatment) and new perceptions of xenobiotic efficacy and/or toxicity. This workshop will review the science and initiate discussions on multiple topics, including a) identification of biomarkers of toxicity for alterations in gut microbial function, b) if changes in the microbiome can affect efficacy of medicines and c) if exposure to xenobiotics can eventually result in a disease state through changes in the microbiome.  Conclusions from his workshop will help determine where the data gaps are so that researchers can start answering these questions.

WORKSHOP GOAL
To identify data gaps that can be addressed to help determine if alterations in the gut microbiome have an effect on human health.

guthealth

WORKSHOP AIMS
1.  To discuss and review the current science on the gut microbiome and identify areas of interest regarding its role in human health
2.  To discuss our understanding on how xenobiotic toxicity affects the microbiome
3.  To understand if there are biomarkers of disease or organ damage due to:
     -  Alterations of microbiome structure and function
     -  Endogenous microbial metabolites

CONFIRMED SPEAKERS 

Elena Biagi, University of Bologna                Kun Lu, University of North Carolina, Chapel Hill
Carrie Brodmerkel, Janssen                           Jeremy Nicholson, Imperial College London   
Mark Brown, Cleveland Clinic                        Andrew Patterson, Pennsylvania State University
Carl Cerniglia, US FDA, NCTR                        Gary Perdew, Pennsylvania State University
Eugene Chang, University of Chicago           Joseph Petrosino, Baylor College of Medicine
Julia Cui, University of Washington              Nathan Price, Institute for Systems Biology
Anna Mae Diehl, Duke University                  Mohan Raizada, University of Florida
Rodney Dietart, Cornell University                Barbara Reherhman, NIDDK
Aaron Erickson, University of Missouri
Marijke Faas, University of Groningen

To receive updates, please fill in the following information:
 
Sorry, but your browser does not support frames.

REGISTRATION WILL OPEN IN EARLY 2018.

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Committee Publications