Translational Biomarkers of Neurotoxicity (NeuTox) Committee

Mission Statement

The committee’s mission is to identify biomarkers for improving the prediction of neurotoxicity and seizurogenic compounds using microelectrode array (MEA).

Working Groups

  • Translational Biomarkers of Neurotoxicity

    This group is working toward identifying biomarkers of improving the prediction of neurotoxicity and identifying correlations in behavioral, imaging, and neuropathological endpoints. A phase 2
    study was launched to validate a set of biomarkers of neurotoxicity.

  • Microelectrode Array Subteam

    This group is working toward characterizing the predictivity of seizurogenic activity using MEA technology. A final analysis of data generated from a multi-site study is expected by early 2023.

  • Think Tank Planning Subteam

    A subteam was formed to plan a small Think Tank workshop where participants will
    discuss possible new areas of focus and next steps.

HESI Staff

Leadership Team

  • Tucker Patterson, PhD

    U.S. Food & Drug Administration

  • Ruth Roberts, PhD, FRSB, FRCPath

    ApconiX, Ltd.

Committee Publications

Changes in the Metabolome and microRNA Levels in Biological Fluids Might Represent Biomarkers of Neurotoxicity: A Trimethyltin Study

Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at ...

Read more

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Events

Society of Toxicology Meeting 2023

Nashville, TN, USA

A number of HESI committees will have presentations and posters at the Society of Toxicology Meeting in Nashville, TN.

Read more

HESI at ICT2022 Symposium

Maastricht, The Netherlands

HESI will be attending the International Congress of Toxicology in Maastricht, Netherlands from 18-21 September 2022.

Read more

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