Emerging Systems Toxicology for Assessment of Risk

Emerging Systems Toxicology for the Assessment of Risk

Mission Statement

The mission of HESI’s Emerging Systems Toxicology for Assessment of Risk (eSTAR) Committee is to develop and deliver innovative systems toxicology approaches for risk assessment. The Committee aims to catalyze adoption of new translational and predictive tools that guide decision-making based on mechanistic understanding of toxicological response.

Committee Contacts

HESI Staff

Syril D. Pettit
spettit@hesiglobal.org

Lauren Peel
lpeel@hesiglobal.org

Leadership Team

Alison Harrill, PhD
National Institute of Environmental Health Sciences

Carole Yauk, PhD
Health Canada

Fact Sheet

Committee Newsletters

Committee Events

WP_Query Object
(
    [query] => Array
        (
            [post_type] => event
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [before] => 2030-12-31
            [after] => 2015-01-01
            [tags] => Genomics
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                    [0] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2030-12-31
                            [compare] => <=
                        )

                    [1] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2015-01-01
                            [compare] => >=
                        )

                )

            [paged] => 1
            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [field] => name
                            [terms] => Genomics
                        )

                )

            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => ASC
        )

    [query_vars] => Array
        (
            [post_type] => event
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [before] => 2030-12-31
            [after] => 2015-01-01
            [tags] => Genomics
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                    [0] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2030-12-31
                            [compare] => <=
                        )

                    [1] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2015-01-01
                            [compare] => >=
                        )

                )

            [paged] => 1
            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [field] => name
                            [terms] => Genomics
                        )

                )

            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => ASC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [static] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 211
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
             => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [terms] => Array
                                (
                                    [0] => Genomics
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_11_term_relationships
                )

            [queried_terms] => Array
                (
                    [post_tag] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Genomics
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_11_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [1] => Array
                        (
                            [0] => Array
                                (
                                    [key] => _ilsi_date
                                    [value] => 2030-12-31
                                    [compare] => <=
                                )

                            [1] => Array
                                (
                                    [key] => _ilsi_end_date
                                    [value] => 2015-01-01
                                    [compare] => >=
                                )

                            [relation] => AND
                        )

                    [relation] => AND
                )

            [relation] => AND
            [meta_table] => wp_11_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_11_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_11_postmeta
                    [1] => mt1
                    [2] => mt2
                )

            [clauses:protected] => Array
                (
                    [wp_11_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [alias] => wp_11_postmeta
                            [cast] => CHAR
                        )

                    [mt1] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2030-12-31
                            [compare] => <=
                            [alias] => mt1
                            [cast] => CHAR
                        )

                    [mt2] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2015-01-01
                            [compare] => >=
                            [alias] => mt2
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => SELECT SQL_CALC_FOUND_ROWS  wp_11_posts.ID FROM wp_11_posts  LEFT JOIN wp_11_term_relationships ON (wp_11_posts.ID = wp_11_term_relationships.object_id) INNER JOIN wp_11_postmeta ON ( wp_11_posts.ID = wp_11_postmeta.post_id )  INNER JOIN wp_11_postmeta AS mt1 ON ( wp_11_posts.ID = mt1.post_id )  INNER JOIN wp_11_postmeta AS mt2 ON ( wp_11_posts.ID = mt2.post_id ) WHERE 1=1  AND ( 
  wp_11_term_relationships.term_taxonomy_id IN (211)
) AND ( 
  wp_11_postmeta.meta_key = '_ilsi_date' 
  AND 
  ( 
    ( mt1.meta_key = '_ilsi_date' AND mt1.meta_value <= '2030-12-31' ) 
    AND 
    ( mt2.meta_key = '_ilsi_end_date' AND mt2.meta_value >= '2015-01-01' )
  )
) AND wp_11_posts.post_type = 'event' AND (wp_11_posts.post_status = 'publish') GROUP BY wp_11_posts.ID ORDER BY wp_11_postmeta.meta_value ASC LIMIT 0, 5
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 4250
                     => 30
                     => 2016-10-19 15:21:51
                    [post_date_gmt] => 2016-10-19 20:21:51
                    [post_content] => 
                    [post_title] => Workshop on Advances and Roadblocks for use of Genomics Data in Cancer Risk Assessment for Drugs and Chemicals
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => application-of-genomics-to-cancer-risk-assessment-workshop
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-05-24 12:32:37
                    [post_modified_gmt] => 2017-05-24 17:32:37
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://hesiglobal.org/?post_type=event&p=4250
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 1
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 4250
             => 30
             => 2016-10-19 15:21:51
            [post_date_gmt] => 2016-10-19 20:21:51
            [post_content] => 
            [post_title] => Workshop on Advances and Roadblocks for use of Genomics Data in Cancer Risk Assessment for Drugs and Chemicals
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => application-of-genomics-to-cancer-risk-assessment-workshop
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2017-05-24 12:32:37
            [post_modified_gmt] => 2017-05-24 17:32:37
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => http://hesiglobal.org/?post_type=event&p=4250
            [menu_order] => 0
            [post_type] => event
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 1
    [max_num_pages] => 1
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 1
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 8e92d41acff7d5aecf8d908f58bdf386
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Committee Publications

All Publications

The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog

MicroRNAs (miRNA) are ~19-25 nucleotide long RNA molecules that fine tune gene expression through the inhibition of translation or degradation of the mRNA through incorporation into the RNA induced silencing complex (RISC). MicroRNAs are stable in the serum and plasma, are detectable in a wide variety of body fluids, are conserved across veterinary species and humans and are expressed in a tissue specific manner. They can be detected at low concentrations in circulation in animals and humans, generating interest in the utilization of miRNAs as serum and/or plasma based biomarkers of tissue injury. MicroRNA tissue profiling in rodents has been published, but sample an insufficient number of organs of toxicologic interest using microarray or qPCR technologies for miRNA detection. Here we impart an improved rat microRNA body atlas consisting of 21 and 23 tissues of toxicologic interest from male and female Sprague Dawley rats respectively, using Illumina miRNA sequencing. Several of the authors created a dog miRNA body atlas and we collaborated to test miRNAs conserved in rat and dog pancreas in caerulein toxicity studies utilizing both species.

Read more

Importance of Investigating Epigenetic Alterations for Industry and Regulators: An Appraisal of Current Efforts by the Health and Environmental Sciences Institute

Recent technological advances have led to rapid progress in the characterization of epigenetic modifications that control gene expression in a generally heritable way, and are likely involved in defining cellular phenotypes, developmental stages and disease status from one generation to the next.

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Genomics
            [authors] => true
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Genomics
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => Genomics
            [authors] => true
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [field] => name
                            [terms] => Genomics
                        )

                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [static] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
             => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
            [taxonomy] => ilsi_committee
            [term_id] => Genomics
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => ilsi_committee
                            [terms] => Array
                                (
                                    [0] => Genomics
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_11_term_relationships
                )

            [queried_terms] => Array
                (
                    [ilsi_committee] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => Genomics
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_11_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_11_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_11_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_11_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_11_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [alias] => wp_11_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => SELECT SQL_CALC_FOUND_ROWS  wp_11_posts.ID FROM wp_11_posts  LEFT JOIN wp_11_term_relationships ON (wp_11_posts.ID = wp_11_term_relationships.object_id) INNER JOIN wp_11_postmeta ON ( wp_11_posts.ID = wp_11_postmeta.post_id ) WHERE 1=1  AND ( 
  wp_11_term_relationships.term_taxonomy_id IN (313)
) AND ( 
  wp_11_postmeta.meta_key = '_ilsi_date'
) AND wp_11_posts.post_type = 'publication' AND (wp_11_posts.post_status = 'publish') GROUP BY wp_11_posts.ID ORDER BY wp_11_postmeta.meta_value DESC LIMIT 0, 5
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 6555
                     => 57
                     => 2017-12-15 11:39:01
                    [post_date_gmt] => 2017-12-15 16:39:01
                    [post_content] => 
                    [post_title] => Demodifying RNA for Transcriptomic Analyses of Archival Formalin-Fixed Paraffin-Embedded Samples
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => demodifying-rna-for-transcriptomic-analyses-of-archival-formalin-fixed-paraffin-embedded-samples
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-12-21 10:46:36
                    [post_modified_gmt] => 2017-12-21 15:46:36
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://hesiglobal.org/?post_type=publication&p=6555
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 6554
                     => 57
                     => 2017-12-15 11:27:57
                    [post_date_gmt] => 2017-12-15 16:27:57
                    [post_content] => 
                    [post_title] => Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => development-and-validation-of-a-high-throughput-transcriptomic-biomarker-to-address-21st-century-genetic-toxicology-needs
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-12-15 11:28:20
                    [post_modified_gmt] => 2017-12-15 16:28:20
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://hesiglobal.org/?post_type=publication&p=6554
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 4886
                     => 57
                     => 2017-08-01 14:34:07
                    [post_date_gmt] => 2017-08-01 19:34:07
                    [post_content] => 
                    [post_title] => The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-rat-microrna-body-atlas-evaluation-of-the-microrna-content-of-rat-organs-through-deep-sequencing-and-characterization-of-pancreas-enriched-mirnas-as-biomarkers-of-pancreatic-toxicity-in-the-rat-a
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-08-01 14:34:07
                    [post_modified_gmt] => 2017-08-01 19:34:07
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://hesiglobal.org/?post_type=publication&p=4886
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 1983
                     => 12
                     => 2016-04-17 21:38:50
                    [post_date_gmt] => 2016-04-18 02:38:50
                    [post_content] => 
                    [post_title] => Mining the Archives: A Cross-Platform Analysis of Gene Expression Profiles in Archival Formalin-Fixed Paraffin-Embedded (FFPE) Tissue
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => mining-the-archives-a-cross-platform-analysis-of-gene-expression-profiles-in-archival-formalin-fixed-paraffin-embedded-ffpe-tissue
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-04-04 11:49:48
                    [post_modified_gmt] => 2017-04-04 16:49:48
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=1983
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 1969
                     => 12
                     => 2016-04-17 21:48:55
                    [post_date_gmt] => 2016-04-18 02:48:55
                    [post_content] => 
                    [post_title] => Importance of Investigating Epigenetic Alterations for Industry and Regulators: An Appraisal of Current Efforts by the Health and Environmental Sciences Institute
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => importance-of-investigating-epigenetic-alterations-for-industry-and-regulators-an-appraisal-of-current-efforts-by-the-health-and-environmental-sciences-institute
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2017-04-04 11:52:42
                    [post_modified_gmt] => 2017-04-04 16:52:42
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=1969
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 5
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 6555
             => 57
             => 2017-12-15 11:39:01
            [post_date_gmt] => 2017-12-15 16:39:01
            [post_content] => 
            [post_title] => Demodifying RNA for Transcriptomic Analyses of Archival Formalin-Fixed Paraffin-Embedded Samples
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => demodifying-rna-for-transcriptomic-analyses-of-archival-formalin-fixed-paraffin-embedded-samples
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2017-12-21 10:46:36
            [post_modified_gmt] => 2017-12-21 15:46:36
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => http://hesiglobal.org/?post_type=publication&p=6555
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 27
    [max_num_pages] => 6
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 1
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 9e28d525af07734abc9f2f93b5515154
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)