Application of Genomics to Mechanism Based Risk Assessment Technical Committee

 

Application of Genomics to Mechanism Based Risk Assessment Technical Committee

Mission Statement

The mission of HESI’s Genomics Committee is to advance the scientific basis for the development and application of genomic methodologies to mechanism-based risk assessment; to address scientific issues relating to the use of these new technologies as a means for understanding toxic response and mechanisms; and to provide a scientific forum for a consensus-based approach to interpreting and applying these data.

The HESI Genomics Committee executes its mission via multiple working groups with distinct projects and activities.  Active programs include a study using microarray data to assess doxorobucin toxicity in rodents (the study will compare array data with other metrics such as histopathology and serum chemistry) and planning for a workshop featuring case studies of the use of toxicogenomic data for safety and risk assessment.  The Committee is completing manuscripts on control animal microarray data, use of genomics and PCR to distinguish direct and indirect acting genotoxins, and the results of a survey on the current state of practice in the field of toxicogenomics.

Committee Contacts

HESI Staff

Raegan O'Lone, PhD
rolone@hesiglobal.org

Leadership Team

Alison Harrill, PhD
University of Arkansas for Medical Sciences

Carole Yauk, PhD
Health Canada

Members and Fact Sheet

Committee Events

Events From 2030-12-31—2015-01-01

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Committee Publications

All Publications

Importance of Investigating Epigenetic Alterations for Industry and Regulators: An Appraisal of Current Efforts by the Health and Environmental Sciences Institute

Recent technological advances have led to rapid progress in the characterization of epigenetic modifications that control gene expression in a generally heritable way, and are likely involved in defining cellular phenotypes, developmental stages and disease status from one generation to the next.

Read more

Sources of Variance in Baseline Gene Expression in the Rodent Liver

The use of gene expression profiling in both clinical and laboratory settings would be enhanced by better characterization of variation due to individual, environmental, and technical factors.

Read more

Current and Future Applications of Toxicogenomics: Results Summary of a Survey From the HESI Genomics State of Science Subcommittee

In spite of the application of toxicogenomic (TGx) data to the field of toxicology for the past 10 years, the broad implementation and full impact of TGx for chemical and drug evaluation to improve decision making within organizations and by policy makers has not been achieved.

Read more

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