The threshold of toxicological concern (TTC) concept is well established for assessing human safety of food-contact substances and has been reapplied for a variety of endpoints, including carcinogenicity, teratogenicity, and reproductive toxicity.
Animal Alternatives in Environmental Assessment Committee
HESI's Animal Alternatives in Environmental Risk Assessment Committee
To ensure the development of a sound technical basis for alternative test methods as a means to reduce, refine, or replace standard ecotoxicity test procedures around the globe.
The committee aims to provide a forum to coordinate the debates and best emerging practices of the alternatives and animal model development sciences to meet existing hazard assessment, effluent assessment, risk assessment, classification and labeling, and other regulatory needs.
The fish early-life stage (FELS) test (Organisation for Economic Co-operation and Development [OECD] test guideline 210) is the primary test used internationally to estimate chronic fish toxicity in support of ecological risk assessments and chemical management programs.
Endocrine disruption is considered a highly relevant hazard for environmental risk assessment of chemicals, plant protection products, biocides and pharmaceuticals.
Animal alternatives research has historically focused on human safety assessments and has only recently been extended to environmental testing.
Animal alternative tests are gaining serious consideration in an array of environmental sciences, particularly as they relate to sound management of chemicals and wastewater discharges.